HLA-B27-associated uveitis with a chorioretinitis manifestation.

Abstract

A 29-year-old man who had been treated for acute anterior uveitis in a local medical office and observed for 1 month presented complaining of distorted vision in his left eye for 1 week. On ophthalmic examination, the anterior segment was relatively quiet with few cells. A posterior segment examination revealed cystoid macular edema and multiple splinter retinal hemorrhages. Results of all laboratory and imaging studies were negative, except for a positive HLA-B27 haplotype. Fluorescein angiography revealed massive leakage in the mid and late phase, consistent with chorioretinitis. Periocular corticosteroid injections and oral prednisolone were administered. The patient responded to the treatment well with subsequent resolution of chorioretinitis 2 months later. Although rare, chorioretinitis can occur in the setting of uveitis associated with HLA-B27 and seems to respond well to corticosteroid treatment.

• Authors: Jack Yu-Shih Lin, Shun-Ling Lin, Wei-Lin Chen, Ying-Shan Chen
• Journal: Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye (Ophthalmic Surg Lasers Imaging) 2005 Mar-Apr Vol. 36 Issue 2 Pg. 158-62 ISSN: 1542-8877 [Print] United States
• PMID: 15792320 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Glucocorticoids
• HLA-B27 Antigen
• Triamcinolone Acetonide

Topics

• Adult
• Anti-Inflammatory Agents (administration & dosage)
• Chorioretinitis (complications, drug therapy, genetics, metabolism)
• Choroid (pathology)
• Fluorescein Angiography
• Fundus Oculi
• Glucocorticoids (administration & dosage)
• HLA-B27 Antigen (genetics, metabolism)
• Haplotypes
• Humans
• Injections
• Male
• Retina (pathology)
• Triamcinolone Acetonide (administration & dosage)
• Uveitis, Anterior (complications, drug therapy, genetics, metabolism)
• Visual Acuity