Nerve agent poisoning is characterized by the rapid progression of toxic signs, including hypersecretions,
tremor, convulsions and profound brain damage. In the political arena of today's world, the threat of
nerve agent use against military troops has prompted armies to search for prophylactic protection. The two main strategies for prophylaxis include
biological scavengers that can bind or cleave
nerve agents before they react with
acetylcholinesterase, and antidotes as prophylactic treatment.
Pyridostigmine is the current pretreatment for
nerve agent poisoning and is in use by most of the armed forces in Western countries. However, since
pyridostigmine barely crosses the blood-brain barrier it provides no protection against
nerve agent-induced central injury.
Pyridostigmine is ineffective when administered without post-exposure treatment adjuncts. Therefore, other directions for prophylactic treatment should be explored. These include combinations of
carbamates (reversible AChE inhibitors) and central
anticholinergics or
NMDA receptor antagonists,
benzodiazepines or partial agonists for
benzodiazepine receptor, and other central AChE inhibitors approved for
Alzheimer's disease. The transdermal route is an alternative way for delivering the prophylactic agent. Administration of prophylaxis can be extended also for civilian use during wartime.