Abstract | OBJECTIVES: METHODS: RESULTS: The observed second-trimester rate of triploidy was 0.37 per 10 000 fetuses. Two different serum marker patterns were seen in triploid pregnancies, distinguished from each other by typically very high or very low levels of total hCG or free beta-hCG. The median maternal ages were respectively 33 years for triploidy with human chorionic gonadotrophin levels < 1.0 MoM, and 26 years for those with hCG levels > or =1.0 MoM. Fifty-seven percent of the pregnancies with a triploid fetus had a risk estimate > or =1:100 for trisomy 18 alone, 10% had an alpha-fetoprotein > or =2.5 MoM, 5% were screen positive for Down syndrome alone, and 19% had an increased risk or positive results for more than one anomaly. CONCLUSION:
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Authors | Tianhua Huang, Eva Alberman, Nicholas Wald, Anne M Summers |
Journal | Prenatal diagnosis
(Prenat Diagn)
Vol. 25
Issue 3
Pg. 229-33
(Mar 2005)
ISSN: 0197-3851 [Print] England |
PMID | 15791661
(Publication Type: Journal Article)
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Copyright | Copyright 2005 John Wiley & Sons, Ltd. |
Chemical References |
- Biomarkers
- Chorionic Gonadotropin
- alpha-Fetoproteins
- inhibin A
- Inhibins
- Estriol
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Topics |
- Adult
- Biomarkers
(blood)
- Chorionic Gonadotropin
(blood)
- Chromosomes, Human, Pair 18
- Down Syndrome
(blood, diagnosis, epidemiology)
- Estriol
(blood)
- Female
- Fetal Diseases
(diagnosis)
- Humans
- Inhibins
(blood)
- London
(epidemiology)
- Mass Screening
- Neural Tube Defects
(blood, diagnosis, epidemiology)
- Ontario
(epidemiology)
- Pregnancy
- Pregnancy Trimester, Second
- Prenatal Diagnosis
- Prevalence
- Trisomy
(diagnosis)
- alpha-Fetoproteins
(analysis)
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