Interleukin-1 receptor antagonist gene polymorphism in Taiwanese patients with gout.

Abstract

OBJECTIVE:

The purpose of this study was to examine whether interleukin-1 receptor antagonist (IL-1Ra) gene polymorphism is a marker of susceptibility to or of the clinical characteristics of gout in Taiwanese patients.

METHODS:

196 Taiwanese patients with gout and 103 unrelated normal healthy control subjects living in central Taiwan were studied. Polymorphism of the gene for IL-1Ra was typed from genomic DNA. Allelic frequencies and carriage rates were compared between gout patients and control subjects. The relationship between IL-1Ra genotypes and the clinical characteristics of gout was also evaluated.

RESULTS:

No significant differences were observed in genetic and allelic frequencies of the IL-1Ra gene polymorphism between patients with gout and healthy control subjects. Furthermore, we did not detect any association of IL-1Ra genotype with the clinical and laboratory profiles in patients with gout.

CONCLUSION:

The results from the present study suggest that the interleukin-1 receptor antagonist gene polymorphism is not a genetic marker of susceptibility to gout for Taiwanese. Furthermore, our study also suggests that the IL-1Ra gene polymorphism is unrelated to the clinical characteristics of gout.

• Authors: S F Lo, C M Huang, C H Tsai, M L Chen, F J Tsai
• Journal: Clinical and experimental rheumatology (Clin Exp Rheumatol) 2005 Jan-Feb Vol. 23 Issue 1 Pg. 85-8 ISSN: 0392-856X [Print] Italy
• PMID: 15789892 (Publication Type: Comparative Study, Journal Article)

Chemical References

• IL1RN protein, human
• Interleukin 1 Receptor Antagonist Protein
• Sialoglycoproteins

Topics

• Female
• Gene Frequency (genetics)
• Genetic Predisposition to Disease (genetics)
• Genotype
• Gout (genetics)
• Heterozygote
• Humans
• Interleukin 1 Receptor Antagonist Protein
• Male
• Polymorphism, Genetic (genetics)
• Sialoglycoproteins (genetics)
• Taiwan