Abstract | BACKGROUND: PATIENTS AND METHODS: RESULTS: The maximal tolerated dose of thalidomide was 150 mg/day. All patients complained of sedation and other neurological or digestive adverse effects. In all but one patient the adverse effects disappeared after thalidomide withdrawal or dose reduction. Interleukin-2 administration caused a flu-like syndrome and a reaction at the injection site. During treatment, alpha-fetoprotein increased in six patients, remained stable in two and decreased in one. Eight patients showed tumour progression and one had a stable disease. Eight patients died. The median survival was 9.9 (range 2.6-18.6) months. CONCLUSION:
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Authors | F Mirici Cappa, M C Cantarini, G Magini, A Zambruni, C Bendini, V Santi, M Bernardi, F Trevisani |
Journal | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
(Dig Liver Dis)
Vol. 37
Issue 4
Pg. 254-9
(Apr 2005)
ISSN: 1590-8658 [Print] Netherlands |
PMID | 15788209
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Antineoplastic Agents, Hormonal
- Immunosuppressive Agents
- Interleukin-2
- alpha-Fetoproteins
- Thalidomide
- Megestrol
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Topics |
- Aged
- Antineoplastic Agents, Hormonal
(administration & dosage, adverse effects)
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects, therapeutic use)
- Carcinoma, Hepatocellular
(complications, drug therapy, mortality)
- Diarrhea
(chemically induced)
- Dose-Response Relationship, Drug
- Female
- Humans
- Immunosuppressive Agents
(administration & dosage, adverse effects)
- Interleukin-2
(administration & dosage, adverse effects)
- Liver Cirrhosis
(complications, drug therapy)
- Liver Neoplasms
(complications, drug therapy, mortality)
- Male
- Megestrol
(administration & dosage, adverse effects)
- Middle Aged
- Neoplasm Staging
- Pilot Projects
- Survival Analysis
- Survival Rate
- Thalidomide
(administration & dosage, adverse effects)
- Treatment Outcome
- Tremor
(chemically induced)
- alpha-Fetoproteins
(metabolism)
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