Diagnosis and monitoring a case of light-chain deposition disease in the kidney using a new, sensitive immunoassay.

Abstract

A 59-year-old male was diagnosed with nephrotic syndrome secondary to light-chain deposition disease. There was no other evidence of a B cell clonal disorder or amyloidosis; circulating free light chains were identified using a new immunoassay (Freelite) and used to monitor disease progression. Improvement in renal function and proteinuria following VAMP chemotherapy correlated with a reduction in circulating light-chain levels. This case demonstrates a new tool in monitoring light-chain deposition disease in the kidney.

• Authors: Ian Brockhurst, Kevin P G Harris, Claire S Chapman
• Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (Nephrol Dial Transplant) Vol. 20 Issue 6 Pg. 1251-3 (Jun 2005) ISSN: 0931-0509 [Print] England
• PMID: 15784642 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulin kappa-Chains
• Immunoglobulin lambda-Chains
• Vincristine
• Prednisolone
• Azathioprine
• Methotrexate

Topics

• Antineoplastic Combined Chemotherapy Protocols (administration & dosage)
• Azathioprine (administration & dosage)
• Basement Membrane (metabolism, ultrastructure)
• Disease Progression
• Humans
• Hypergammaglobulinemia (blood, diagnosis, drug therapy, pathology)
• Immunoassay (methods)
• Immunoglobulin kappa-Chains (blood)
• Immunoglobulin lambda-Chains (blood)
• Kidney (pathology)
• Kidney Tubules (metabolism, ultrastructure)
• Male
• Methotrexate (administration & dosage)
• Middle Aged
• Nephrotic Syndrome (etiology)
• Prednisolone (administration & dosage)
• Vincristine (administration & dosage)