Clinical and bacteriological efficacy of 5-day telithromycin in acute maxillary sinusitis: a pooled analysis.

Abstract

OBJECTIVES:

To compare the efficacy and tolerability of a 5-day course of telithromycin (800 mg once daily) with a 10-day course of telithromycin or standard comparators (amoxicillin-clavulanate 500/125 mg three times daily or cefuroxime axetil 250 mg twice daily) in patients with acute maxillary sinusitis (AMS).

METHODS:

Data from three randomised double blind studies were pooled. The studies included patients with clinical symptoms of AMS and sinus X-ray findings of total opacity, air-fluid levels or mucosal thickening.

RESULTS:

Pooled analysis of results for 5-day telithromycin revealed overall clinical cure rates of 83.6% (383/458 patients) at post-therapy (days 17-24) and 78.9% (330/418 patients) at late post-therapy (days 31-45) in the per-protocol population. Clinical cure rates at post-therapy were equivalent to those observed with 10-day telithromycin (82.5% vs 81.7%) or comparator treatment (80.9% vs 77.4%). Moreover, clinical cure rates exceeded 80% in subgroups of patients of interest, including those with severe infection and those fulfilling more stringent criteria for bacterial AMS. A satisfactory bacteriological outcome was achieved in 87.6% of patients. The 5-day telithromycin regimen was well tolerated.

CONCLUSIONS:

Telithromycin once daily for 5 days offers effective treatment for AMS and is comparable to 10-day courses of standard treatments.

• Authors: K Roos, G Tellier, M Baz, B Leroy, M Rangaraju
• Journal: The Journal of infection (J Infect) Vol. 50 Issue 3 Pg. 210-20 (Apr 2005) ISSN: 0163-4453 [Print] England
• PMID: 15780415 (Publication Type: Comparative Study, Journal Article, Meta-Analysis)

Chemical References

• Anti-Bacterial Agents
• Ketolides
• Amoxicillin-Potassium Clavulanate Combination
• telithromycin
• Cefuroxime
• cefuroxime axetil

Topics

• Acute Disease
• Adolescent
• Adult
• Aged
• Amoxicillin-Potassium Clavulanate Combination (therapeutic use)
• Anti-Bacterial Agents (administration & dosage, adverse effects, therapeutic use)
• Cefuroxime (analogs & derivatives, therapeutic use)
• Drug Administration Schedule
• Drug Resistance, Bacterial
• Female
• Humans
• Ketolides (administration & dosage, adverse effects, therapeutic use)
• Male
• Maxillary Sinusitis (drug therapy, microbiology)
• Middle Aged