[Assessment of efficacy of migraine attack treatment with lysine acetylsalicylate and metoclopramide].

Abstract

Migraine is a common medical condition affecting nearly 10% of population in Poland. The aim of the study was to evaluate the efficacy, tolerability and safety of migraine abortive treatment with the combination of lysine acetylsalicylate and metoclopramide (1620 mg LAS + 10 mg MTC--Migpriv). 1620 patients with migraine, meeting International Headache Society (IHS) criteria were included in the study. The aim of the study was also determination of the number of patients having headache relief and no nausea or vomiting two hours after the drug intake. In most patients the migraine symptoms disappeared after a single dose administration. Reported adverse events were rare and short lasting. The study showed that metoclopramide was well tolerated and effective at relieving migraine attack symptoms.

• Authors: Adam Stepień, Wojciech Kozubski
• Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego (Pol Merkur Lekarski) Vol. 17 Issue 102 Pg. 615-9 (Dec 2004) ISSN: 1426-9686 [Print] Poland
• Vernacular Title: Ocena skuteczności leczenia napadu migreny acetylosalicylanem lizyny w połaczeniu z chlorowodorkiem metoklopramidu.
• PMID: 15771135 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Dopamine Antagonists
• Lysine
• Metoclopramide
• Aspirin
• acetylsalicylic acid lysinate

Topics

• Adolescent
• Adult
• Aged
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Aspirin (analogs & derivatives, therapeutic use)
• Dopamine Antagonists (therapeutic use)
• Drug Tolerance
• Female
• Humans
• Lysine (analogs & derivatives, therapeutic use)
• Male
• Metoclopramide
• Middle Aged
• Migraine Disorders (drug therapy)