Abstract |
To test a hypothesis of compartmentalized pathogenesis of different types of arthritis, namely inflammatory arthritis (IA) and osteoarthritis (OA), synovial and cartilage biopsies were examined for the expression of TNF and IL-1 receptors. In cartilage, we found constitutive expression of all receptors in normal tissues, and decreased expression of signal-transducing receptors in pathological chondrocytes. In synovium, there was a lower expression of signal-transducing receptors in cases of OA compared to those of IA. In OA, the three signal-transducing receptors were more abundantly expressed in cartilage, while in IA they were mainly present in synovial tissue (TNFRp75 being expressed more than p55). IL-1 decoy receptor type II was low or absent in synovial tissues, but present in cartilage. The increased expression of TNFRp75 and IL-1RI in OA cartilage, compared to IA, in addition to the abundant local cytokine production, strengthens the hypothesis of autocrine/paracrine action by inflammatory cytokines in the pathogenesis of cartilage damage.
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Authors | Tania Silvestri, Lia Pulsatelli, Paolo Dolzani, Luigi Frizziero, Andrea Facchini, Riccardo Meliconi |
Journal | Rheumatology international
(Rheumatol Int)
Vol. 26
Issue 4
Pg. 360-8
(Feb 2006)
ISSN: 0172-8172 [Print] Germany |
PMID | 15770481
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Receptors, Interleukin-1
- Receptors, Tumor Necrosis Factor
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Arthritis, Rheumatoid
(metabolism, pathology)
- Cartilage, Articular
(metabolism, pathology)
- Chondrocytes
(metabolism, pathology)
- Female
- Humans
- Image Processing, Computer-Assisted
- Immunohistochemistry
- Male
- Middle Aged
- Osteoarthritis, Knee
(metabolism, pathology)
- Receptors, Interleukin-1
(metabolism)
- Receptors, Tumor Necrosis Factor
(metabolism)
- Signal Transduction
(physiology)
- Synovial Membrane
(metabolism, pathology)
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