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In vivo expression of inflammatory cytokine receptors in the joint compartments of patients with arthritis.

Abstract
To test a hypothesis of compartmentalized pathogenesis of different types of arthritis, namely inflammatory arthritis (IA) and osteoarthritis (OA), synovial and cartilage biopsies were examined for the expression of TNF and IL-1 receptors. In cartilage, we found constitutive expression of all receptors in normal tissues, and decreased expression of signal-transducing receptors in pathological chondrocytes. In synovium, there was a lower expression of signal-transducing receptors in cases of OA compared to those of IA. In OA, the three signal-transducing receptors were more abundantly expressed in cartilage, while in IA they were mainly present in synovial tissue (TNFRp75 being expressed more than p55). IL-1 decoy receptor type II was low or absent in synovial tissues, but present in cartilage. The increased expression of TNFRp75 and IL-1RI in OA cartilage, compared to IA, in addition to the abundant local cytokine production, strengthens the hypothesis of autocrine/paracrine action by inflammatory cytokines in the pathogenesis of cartilage damage.
AuthorsTania Silvestri, Lia Pulsatelli, Paolo Dolzani, Luigi Frizziero, Andrea Facchini, Riccardo Meliconi
JournalRheumatology international (Rheumatol Int) Vol. 26 Issue 4 Pg. 360-8 (Feb 2006) ISSN: 0172-8172 [Print] Germany
PMID15770481 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Receptors, Interleukin-1
  • Receptors, Tumor Necrosis Factor
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Arthritis, Rheumatoid (metabolism, pathology)
  • Cartilage, Articular (metabolism, pathology)
  • Chondrocytes (metabolism, pathology)
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Osteoarthritis, Knee (metabolism, pathology)
  • Receptors, Interleukin-1 (metabolism)
  • Receptors, Tumor Necrosis Factor (metabolism)
  • Signal Transduction (physiology)
  • Synovial Membrane (metabolism, pathology)

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