Abstract | OBJECTIVE: ANIMALS: 75 calves. PROCEDURE: 24 hours after challenge with M. haemolytica, 72 calves with clinical signs of respiratory tract disease were randomly assigned to 1 of 12 equal treatment groups. Three nonchallenged, nontreated calves formed a control group. Challenged calves were treated with danofloxacin (6 and 8 mg/kg, SC) and enrofloxacin (8 mg/kg, SC) once. At 1, 2, 6, and 12 hours after treatment, 6 calves from each treatment group were euthanatized. Antimicrobial drug concentrations were assayed in various specimens. Peak plasma concentration (Cmax)-to-minimum inhibitory concentration (MIC; Cmax-to-MIC) ratios and the area under the concentration versus time curve over a 12-hour period-to-MIC ratios (AUC(12h)-to-MIC) were calculat-ed. RESULTS: CONCLUSIONS AND CLINICAL RELEVANCE:
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Authors | Terry N TerHune, Terry L Skogerboe, Valerie K Shostrom, Daniel J Weigel |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 66
Issue 2
Pg. 342-9
(Feb 2005)
ISSN: 0002-9645 [Print] United States |
PMID | 15757137
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Infective Agents
- Fluoroquinolones
- Quinolones
- danofloxacin
- Enrofloxacin
- Ciprofloxacin
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Topics |
- Animals
- Anti-Infective Agents
(pharmacokinetics)
- Bronchoalveolar Lavage
(veterinary)
- Bronchoalveolar Lavage Fluid
(chemistry)
- Cattle
- Chromatography, High Pressure Liquid
(veterinary)
- Ciprofloxacin
(pharmacokinetics)
- Enrofloxacin
- Fluoroquinolones
(pharmacokinetics)
- Lung
(metabolism, microbiology)
- Male
- Mannheimia haemolytica
(pathogenicity)
- Microbial Sensitivity Tests
(veterinary)
- Pasteurellosis, Pneumonic
(metabolism, microbiology)
- Quinolones
(pharmacokinetics)
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