[Comparison of the effectiveness of pentobarbital and thiopental in patients with refractory intracranial hypertension. Preliminary report of 20 patients].

Abstract

OBJECTIVE:

To assess the effectiveness of pentobarbital and thiopental to control raised intracranial pressure (ICP), refractory to first level measures, in patients with severe traumatic brain injury.

MATERIAL AND METHODS:

Prospective, randomized study to compare the effectiveness between two treatments: pentobarbital and thiopental. The patients will be selected from those admitted to the Intensive Care Unit with a severe traumatic brain injury (postresuscitation Glasgow Coma Scale equal or less than 8 points) and raised ICP (ICP>20 mmHg) refractory to first level measures according to the Brain Trauma Foundation guidelines. The adverse effects of both treatments were also collected.

RESULTS:

We present the results of the first 20 patients included. Ten received pentobarbital and the other ten thiopental. There were no statistically significance differences in patients'characteristics (age, sex, severity of the trauma at admission and comorbilities). There were no differences between both groups neither in the Glasgow Coma Scale at admission (thiopental six points; pentobarbital seven points; P=0.26) nor in the admission Cranial Tomography, according to the Traumatic Coma Data Bank Classification. Thiopental treatment controlled raised ICP in five cases and pentobarbital in two cases (P=0.16). Five patients in the thiopental group died and eight in the pentobarbital group (P=0.16). There were no statistically differences between both groups regarding to the presence of hypotension (P=1) or infectious complications.

CONCLUSIONS:

These preliminary results indicate that thiopental could be more effective than pentobarbital in patients with refractory intracranial hypertension. These results support previous experimental findings that show that both treatments are not equal and justify to continue this study.

• Authors: J Pérez-Bárcena, B Barceló, J Homar, J M Abadal, F J Molina, A de la Peña, J Sahuquillo, J Ibáñez
• Journal: Neurocirugia (Asturias, Spain) (Neurocirugia (Astur)) Vol. 16 Issue 1 Pg. 5-12; discussion 12-3 (Feb 2005) ISSN: 1130-1473 [Print] Spain
• Vernacular Title: Comparación de la eficacia del pentobarbital y el tiopental en el control de la hipertensión intracraneal refractaria. Resultados preliminares en una serie de 20 pacientes.
• PMID: 15756405 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• GABA Modulators
• Pentobarbital
• Thiopental

Topics

• Adult
• Cohort Studies
• Female
• GABA Modulators (therapeutic use)
• Humans
• Intracranial Hypertension (diagnosis, drug therapy, physiopathology)
• Male
• Pentobarbital (therapeutic use)
• Prospective Studies
• Refractory Period, Electrophysiological (physiology)
• Severity of Illness Index
• Thiopental (therapeutic use)