Abstract | BACKGROUND: METHODS: The operative gallbladder materials were from five control cases, two cases of non- PBM gallbladder cancer, three of PBM gallbladder cancer, and three of non-neoplastic PBMs. Multiple sampling was performed from each gallbladder. The studies performed were: (1) immunohistochemistry of p53, Ki-67, and Bcl-2; (2) survey of k-ras point mutations; and (3) measurement of telomerase activity in each sample. RESULTS: In the cases of non- PBM cancer, abnormalities from the above studies were detected only in the cancerous lesions. Normal-appearing mucosa did not show Bcl-2 expression or telomerase activity. However, in the cases of PBM cancer, normal-appearing mucosa showed telomerase activity and Bcl-2 expression, but did not show p53, Ki-67, or k-ras abnormalities. In the non-neoplastic PBM, all samples showed Bcl-2 expression, and many showed telomerase activity. CONCLUSIONS:
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Authors | Yasushi Ichikawa, Masako Kamiyama, Hitoshi Sekido, Takashi Ishikawa, Yasuhiko Miura, Noriyuki Kamiya, Tomoyuki Morita, Hiroshi Shimada |
Journal | Journal of hepato-biliary-pancreatic surgery
(J Hepatobiliary Pancreat Surg)
Vol. 11
Issue 1
Pg. 34-9
( 2004)
ISSN: 0944-1166 [Print] Japan |
PMID | 15754044
(Publication Type: Journal Article)
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Chemical References |
- Ki-67 Antigen
- Proto-Oncogene Proteins c-bcl-2
- Tumor Suppressor Protein p53
- Telomerase
- HRAS protein, human
- Proto-Oncogene Proteins p21(ras)
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Topics |
- Gallbladder
(metabolism, pathology)
- Gallbladder Neoplasms
(metabolism, pathology)
- Humans
- Immunohistochemistry
- Ki-67 Antigen
(metabolism)
- Point Mutation
- Precancerous Conditions
(metabolism, pathology)
- Proto-Oncogene Proteins c-bcl-2
(metabolism)
- Proto-Oncogene Proteins p21(ras)
(metabolism)
- Telomerase
(metabolism)
- Tumor Suppressor Protein p53
(metabolism)
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