Abstract | BACKGROUND: Converging neuroimaging and postmortem evidence indicates synaptic terminals are abnormal in schizophrenia. A putative molecular mechanism implicates abnormalities of proteins involved in the presynaptic secretory machinery, including the modulator proteins complexin I and complexin II. OBJECTIVES: To determine the amount and distribution of complexin proteins in the hippocampus of subjects with schizophrenia, in parallel with markers for excitatory and inhibitory nerve terminals. The functional implications were also investigated. DESIGN: SUBJECTS: We studied hippocampal sections from 12 subjects with schizophrenia and 12 subjects with no known neuropsychiatric disorder. RESULTS: CONCLUSIONS: The pathology of hippocampal complexin proteins might play an important role in schizophrenia, especially concerning cognitive disturbances.
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Authors | Ken Sawada, Alasdair M Barr, Masato Nakamura, Kunimasa Arima, Clint E Young, Andrew J Dwork, Peter Falkai, Anthony G Phillips, William G Honer |
Journal | Archives of general psychiatry
(Arch Gen Psychiatry)
Vol. 62
Issue 3
Pg. 263-72
(Mar 2005)
ISSN: 0003-990X [Print] United States |
PMID | 15753239
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adaptor Proteins, Vesicular Transport
- Antipsychotic Agents
- Membrane Transport Proteins
- Nerve Tissue Proteins
- SLC17A7 protein, human
- Slc17a7 protein, rat
- Vesicular Glutamate Transport Protein 1
- Vesicular Inhibitory Amino Acid Transport Proteins
- complexin I
- complexin II
- vesicular GABA transporter
- Ketamine
- Haloperidol
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Topics |
- Adaptor Proteins, Vesicular Transport
- Aged
- Animals
- Antipsychotic Agents
(pharmacology)
- Behavior, Animal
(drug effects)
- Cognition Disorders
(chemically induced, diagnosis, metabolism)
- Disease Models, Animal
- Female
- Haloperidol
(pharmacology)
- Hippocampus
(metabolism, physiopathology)
- Humans
- Immunohistochemistry
- Ketamine
(pharmacology)
- Male
- Maze Learning
(drug effects)
- Membrane Transport Proteins
(metabolism)
- Middle Aged
- Nerve Tissue Proteins
(metabolism, physiology)
- Presynaptic Terminals
(metabolism, physiology)
- Rats
- Rats, Sprague-Dawley
- Schizophrenia
(diagnosis, metabolism, physiopathology)
- Schizophrenic Psychology
- Vesicular Glutamate Transport Protein 1
- Vesicular Inhibitory Amino Acid Transport Proteins
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