[A case of liver metastases from cecal cancer successfully treated with fluorouracil and folinic acid (UFT/LV)].

Abstract

A 76-year-old man had undergone a right hemicolectomy for cecal cancer. Oral UFT (450 mg/day) administration alone was started 2 months following the operation. From a CT scan of the abdomen performed 3 months postoperatively, he was diagnosed with liver metastasis. Because the liver metastasis had progressed, combination oral administration of UFT+LV was started (UFT 450 mg/day, LV 75 mg/day, 4 weeks of therapy followed by a 1-week treatment break). After 1 cycle, a good partial response of that lesion was achieved. The pulmonary metastasis had almost disappeared to within normal limits. In conclusion, this treatment was very safe and effective.

• Authors: Motonobu Saito, Koji Sekikawa, Shinji Ohki, Yoshiyuki Endo, Takashi Ohshima, Toshihiko Fukushima, Masashi Kanazawa, Seiichi Takenoshita
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 32 Issue 2 Pg. 227-9 (Feb 2005) ISSN: 0385-0684 [Print] Japan
• PMID: 15751638 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Drug Combinations
• UFT(R) drug
• Tegafur
• Uracil
• Leucovorin
• Fluorouracil

Topics

• Adenocarcinoma (drug therapy, secondary)
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cecal Neoplasms (pathology, surgery)
• Chemotherapy, Adjuvant
• Colectomy (methods)
• Drug Administration Schedule
• Drug Combinations
• Fluorouracil (administration & dosage)
• Humans
• Leucovorin (administration & dosage)
• Liver Neoplasms (drug therapy, secondary)
• Male
• Tegafur (administration & dosage)
• Uracil (administration & dosage)