[Recurrence of esophageal cancer treated by combination TS-1/CDDP therapy].

Abstract

A 68-year-old man underwent subtotal esophagectomy with two fields lymphadenectomy and postoperative chemotherapy so called low dose FP therapy for advanced esophageal cancer (Stage IIIa, pT 3, pN 1, M 0) in October 1999. As he was diagnosed with a recurrence of esophageal cancer as metastatic lymph node tumors which were placed in the right anterocervical and supraclavicular region in March 2001, he underwent enucleation of metastatic lymph node tumors and postoperative chemoradiation therapy, so-called low-dose FP-R therapy. Recently, since other metastatic lymph node tumors in the neck appeared again in August 2001, he underwent radical neck lymph node dissection and postoperative chemoradiation treatment, so-called FAP-R therapy. In October 2003, a chest CT showed multiple lung tumors. He was diagnosed with multiple metastatic lung tumors originating from esophageal cancer. Then, two courses of a combined chemotherapy consisting of TS-1 and CDDP were administered at an interval of one month. We judged the effect of this chemotherapy to be a partial response (PR), because the largest metastatic lung tumor 18 mm in diameter showed a reduction rate of 81.9%, and other tumors had almost disappeared in the chest CT after the combined therapy. No severe adverse effects of more than grade 3 were observed during this combined therapy. This combined chemotherapy consisting of TS-1 and CDDP may prove effective for treating recurrent cases of esophageal cancer.

• Authors: Masatsugu Hiraki, Seiji Yunotani, Ryo Noguchi, Yukari Shinozaki, Hiroki Tani, Masashi Sakai, Toshiyuki Ishimitsu, Masanobu Tabuchi
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 32 Issue 2 Pg. 219-21 (Feb 2005) ISSN: 0385-0684 [Print] Japan
• PMID: 15751636 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• Drug Combinations
• Pyridines
• S 1 (combination)
• Tegafur
• Oxonic Acid
• Cisplatin

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Chemotherapy, Adjuvant
• Cisplatin (administration & dosage)
• Drug Administration Schedule
• Drug Combinations
• Esophageal Neoplasms (pathology, surgery)
• Esophagectomy
• Humans
• Lung Neoplasms (drug therapy, secondary)
• Lymph Node Excision
• Lymph Nodes (pathology)
• Lymphatic Metastasis
• Male
• Oxonic Acid (administration & dosage)
• Pyridines (administration & dosage)
• Tegafur (administration & dosage)