Peginterferon alfa-2b treatment for patients affected by acute hepatitis C: presentation of six case reports.

Abstract

Acute hepatitis C often progresses to chronic infection (70%). In this clinical study, we evaluated if early treatment with peginterferon alfa-2b can prevent acute hepatitis C from developing into a chronic disease. Six patients with acute hepatitis C, based on a well-documented hepatitis C virus (HCV) seroconversion with high alanine aminotransferase (ALT) levels (> 10 x ULN) and persistent HCV RNA titers after 3 months from disease onset, were consecutively treated with peginterferon alfa-2b at 1.5 microg/kg/weekly/sc for 24 weeks. The viral load was quantified by PCR assay. Response was defined as undetectable HCV RNA and normal ALT levels at the end of therapy and after a 6-month follow-up. All patients completed therapy; at the end of therapy, 5/6 patients (83%) responded and no relapses were observed during follow-up. No correlation was found between treatment response and pretreatment viral load, viral genotype, and interval between acute infection diagnosis and start of therapy.

• Authors: G Scotto, E Palumbo, V Fazio, D C Cibelli, A Saracino, G Angarano
• Journal: Infection (Infection) Vol. 33 Issue 1 Pg. 30-2 (Feb 2005) ISSN: 0300-8126 [Print] Germany
• PMID: 15750757 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antiviral Agents
• Interferon alpha-2
• Interferon-alpha
• RNA, Viral
• Recombinant Proteins
• Polyethylene Glycols
• peginterferon alfa-2b

Topics

• Acute Disease
• Antiviral Agents (therapeutic use)
• Female
• Genotype
• Hepacivirus (drug effects, genetics)
• Hepatitis C (drug therapy)
• Humans
• Interferon alpha-2
• Interferon-alpha (therapeutic use)
• Male
• Middle Aged
• Polyethylene Glycols
• RNA, Viral (blood)
• Recombinant Proteins
• Viral Load