Abstract | PURPOSE: EXPERIMENTAL DESIGN:
Glioblastoma multiforme patients (n = 196) underwent a > or =95% volumetric tumor resection followed by conformal radiation. Their EGFR and EGFRvIII status was determined by immunohistochemistry and survival analyses were done. RESULTS: In our study of glioblastoma multiforme patients, 46% (n = 91) failed to express EGFR, 54% (n = 105) had overexpression of the wild-type EGFR, and 31% (n = 61) also expressed the EGFRvIII. Patients within groups expressing the EGFR, EGFRvIII, or lacking EGFR expression did not differ in age, sex, Karnofsky performance scale score, extent of tumor resection, or radiation. The median overall survival times for patients with tumors having EGFR expression absent, overexpressed only, or mutant ( EGFRvIII) were 0.96, 0.98, and 1.07 years, respectively. However, for patients surviving > or =1 year, these values were 2.03, 2.02, and 1.21 years (P < 0.0001; log-rank test comparing EGFRvIII with all others). This effect remained significant in the multivariate analysis after adjustment for all other cofactors including age and Karnofsky performance scale score (rate ratio 4.34; 95% confidence interval, 2.21-8.51). CONCLUSIONS: Neither the overexpressed wild-type EGFR nor EGFRvIII was an independent predictor of median overall survival in this selected cohort of patients who underwent extensive tumor resection. However, in patients surviving > or =1 year, the expression of EGFRvIII was an independent negative prognostic indicator.
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Authors | Amy B Heimberger, Roman Hlatky, Dima Suki, David Yang, Jeff Weinberg, Mark Gilbert, Raymond Sawaya, Kenneth Aldape |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 11
Issue 4
Pg. 1462-6
(Feb 15 2005)
ISSN: 1078-0432 [Print] United States |
PMID | 15746047
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- epidermal growth factor receptor VIII
- ErbB Receptors
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Cohort Studies
- ErbB Receptors
(analysis)
- Female
- Glioblastoma
(metabolism, pathology)
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Prognosis
- Retrospective Studies
- Survival Analysis
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