Total rate of H pylori
infection, mucosal
inflammation, activity of H pylori
infection, glandular
atrophy and intestinal
metaplasia in 3 839
gastric ulcer patients (78.5%, 97.4%, 82.1%, 61.1% and 64.2%, respectively) were significantly higher than those in 4 102 chronic
gastritis patients (55.0%, 90.3%, 56.2%, 36.8%, and 37.0%, respectively, P<0.05). The rate of H pylori colonization of chronic
gastritis in <30 years, 31-40 years, 41-50 years, 51-60 years, 61-70 years and >70 years age groups in antrum was 33.3%, 41.7%, 53.6%, 57.3%, 50.7%, 43.5%, respectively; in corpus, it was 32.6%, 41.9%, 53.8%, 60.2%, 58.0%, 54.8%, respectively; in angulus, it was 32.4%, 42.1%, 51.6%, 54.5%, 49.7%, 43.5%, respectively. The rate of H pylori colonization of
gastric ulcer in <30 years, 31-40 years, 41-50 years, 51-60 years, 61-70 years and >70 years age groups in antrum was 60.5%, 79.9%, 80.9%, 66.8%, 59.6%, 45.6%, respectively; in corpus, it was 59.7%, 79.6%, 83.6%, 80.1%, 70.6%, 59.1%, respectively; in angulus, it was 61.3%, 77.8%, 75.3%, 68.8%, 59.7%, 45.8%, respectively. The rate of H pylori colonization at antrum was similar to corpus and angulus in patients, below 50 years, with chronic
gastritis and in patients, below 40 years, with
gastric ulcer. In the other age- groups, the rate of H pylori colonization was highest in corpus, lower in antrum and lowest in angulus (all P<0.05). The rates of glandular
atrophy and intestinal
metaplasia were higher and earlier in H pylori-positive patients than those without H pylori
infection (both P<0.01). In comparison of
gastric ulcer patients with chronic
gastritis patients, the rate of glandular
atrophy and intestinal
metaplasia was higher in H pylori-positive patients with
gastric ulcer than in H pylori-positive patients with chronic
gastritis (both P<0.01); the rate of glandular
atrophy and intestinal
metaplasia were also higher in H pylori-negative patients with
gastric ulcer than in H pylori-negative patients with chronic
gastritis (both P<0.01). Both glandular
atrophy and intestinal
metaplasia were much more commonly identified in the angulus than in the antrum, lowest in corpus (all P<0.01).
CONCLUSION: