Cobalt induced changes in immune response and adenosine triphosphatase activities in rats.

Abstract

The immuno-biochemical effects of cobaltous chloride in rats receiving iron-sufficient and deficient diets were investigated. Rats receiving 100 ppm or more cobalt showed a significant reduction in thymus and body weights along with a marked decrease in hemoglobin, hematocrit, sheep agglutinins and plaque forming cells. These effects were more pronounced in rats receiving cobalt mixed with iron-deficient diet than those fed on iron-sufficient diet. The Na+-K+ and mitochondrial (Oligomycin-sensitive) Mg2+ATPase activities in brain and liver of rats fed with iron-deficient diets were decreased significantly. However, the ATPase activities in these tissues from rats fed with cobalt mixed with iron-sufficient diets were not altered.

• Authors: K N Chetty, D S Subba Rao, L Drummond, D Desaiah
• Journal: Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes (J Environ Sci Health B) Vol. 14 Issue 5 Pg. 525-44 ( 1979) ISSN: 0360-1234 [Print] England
• PMID: 157363 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Hemagglutinins
• Hemoglobins
• Cobalt
• Adenosine Triphosphatases

Topics

• Adenosine Triphosphatases (metabolism)
• Animals
• Antibody Formation (drug effects)
• Body Weight (drug effects)
• Brain (drug effects, enzymology)
• Chemical Fractionation
• Cobalt (blood, pharmacology)
• Female
• Hemagglutinins (analysis)
• Hematocrit
• Hemoglobins
• Hemolytic Plaque Technique
• Iron Deficiencies
• Liver (drug effects, enzymology)
• Male
• Organ Size
• Rats
• Thymus Gland (drug effects)