Anticancer effects of a plant lignan 7-hydroxymatairesinol on a prostate cancer model in vivo.

Abstract

Clinical intervention studies and experimental studies with lignan-rich diets suggest that lignans may have inhibitory effects on prostate cancer, but no clinical or experimental studies with purified lignans have been published. The purpose of this study was to investigate the effect of a plant lignan 7-hydroxymatairesinol (HMR) on LNCaP human prostate cancer xenografts in athymic mice. Athymic nude male mice were injected subcutaneously with LNCaP cells. Starting 3 days after tumor cell injections, a control diet or a control diet supplemented with 0.15% or 0.30% of HMR was administered to mice and the tumor take rate and growth was observed for 9 weeks. HMR diet inhibited the growth of LNCaP tumors. Mice treated with HMR had smaller tumor volume, lower tumor take rate, increased proportion of nongrowing tumors, and higher tumor cell apoptotic index compared with controls. Furthermore, the cell proliferation index was reduced in mice receiving the 0.30% HMR diet compared with mice receiving the control diet. Our results suggest that dietary HMR started at the early phase of the tumor development inhibits the growth of the LNCaP human prostate cancer xenografts in athymic male mice.

• Authors: Annika Bylund, Niina Saarinen, Jie-Xian Zhang, Anders Bergh, Anders Widmark, Anders Johansson, Eva Lundin, Herman Adlercreutz, Göran Hallmans, Pär Stattin, Sari Mäkela
• Journal: Experimental biology and medicine (Maywood, N.J.) (Exp Biol Med (Maywood)) Vol. 230 Issue 3 Pg. 217-23 (Mar 2005) ISSN: 1535-3702 [Print] England
• PMID: 15734725 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anticarcinogenic Agents
• Isoflavones
• Lignans
• Phytoestrogens
• hydroxymatairesinol
• Prostate-Specific Antigen

Topics

• Animals
• Anticarcinogenic Agents (therapeutic use)
• Apoptosis (drug effects)
• Carcinoma (pathology)
• Cell Proliferation (drug effects)
• Diet
• Disease Models, Animal
• Humans
• Isoflavones (pharmacology)
• Lignans (chemistry, therapeutic use)
• Male
• Mice
• Mice, Nude
• Models, Biological
• Neoplasm Transplantation
• Phytoestrogens (metabolism, urine)
• Prostate-Specific Antigen (metabolism)
• Prostatic Neoplasms (drug therapy, metabolism, pathology)
• Time Factors
• Tumor Cells, Cultured
• Xenograft Model Antitumor Assays