Abstract |
Mesenchymal chondrosarcoma is a rare, usually highly malignant chondrogenic neoplasm. The diagnosis of mesenchymal chondrosarcoma can be challenging, it nonetheless has important therapeutic and diagnostic implications. Thus, biopsies of mesenchymal chondrosarcomas without conspicuous cartilaginous differentiation cannot be safely distinguished from other small cell mesenchymal neoplasms such as Ewing's sarcoma and peripheral neuroendrocrine tumors, synovial sarcomas and hemangiopericytomas, because all of these neoplasms might show overlapping histological features, and so far, there have been no safe immunohistochemical markers available in order to differentiate these neoplasms. In our study on a large series of mesenchymal chondrosarcomas ( n=30) and other small cell sarcomas (Ewing's sarcomas (n=12), synovial sarcomas (n=6), hemangiopericytomas (n=5), small cell osteosarcomas (n=3), and desmoplastic small round cell tumors (n=1)), we could establish the presence of type II collagen in the extracellular tumor matrix of the small cell areas of mesenchymal chondrosarcomas as a specific and sensitive marker to identify mesenchymal chondrosarcomas and to exclude other small cell neoplasms (except chondroblastic areas in small cell osteosarcomas). In contrast, the S-100 protein was less sensitive and vimentin and total collagen content unspecific for discriminating these neoplasms. Thus, the presence of type II collagen in the extracellular tumor matrix significantly facilitates the diagnosis of mesenchymal chondrosarcomas in the absence of histologically visible chondroid matrix formation.
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Authors | Susanna Müller, Stephan Söder, André M Oliveira, Carrie Y Inwards, Thomas Aigner |
Journal | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
(Mod Pathol)
Vol. 18
Issue 8
Pg. 1088-94
(Aug 2005)
ISSN: 0893-3952 [Print] United States |
PMID | 15731776
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Collagen Type II
- S100 Proteins
- Vimentin
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Topics |
- Biomarkers, Tumor
(analysis)
- Bone Neoplasms
(metabolism, pathology)
- Chondrosarcoma, Mesenchymal
(metabolism, pathology)
- Collagen Type II
(analysis)
- Diagnosis, Differential
- Humans
- Immunohistochemistry
- S100 Proteins
(analysis)
- Sarcoma, Small Cell
(metabolism, pathology)
- Vimentin
(analysis)
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