Abstract | OBJECTIVE: METHODS: RESULTS: The expression of PPARa mRNA in the hepatic tissue of the LPS group was downregulated markedly in comparison to that of the control group. The level of free fatty acid and endotoxin by secreting tumor necrosis factor-a increased and triglyceride accumulated in the liver caused malondialdehyde content to increase, then lipid peroxidation process enhanced and ALT activity increased. Thus, hepatic injury and inflammatory reaction could be accelerated. CONCLUSION:
Endotoxemia can enhance hepatocellular steatosis and lead to NASH due to its downregulating the expression of PPARa mRNA.
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Authors | Xia Li, De Wu Han, Long Feng Zhao, Lei Yin |
Journal | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology
(Zhonghua Gan Zang Bing Za Zhi)
Vol. 13
Issue 2
Pg. 89-91
(Feb 2005)
ISSN: 1007-3418 [Print] China |
PMID | 15727690
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Endotoxins
- PPAR alpha
- RNA, Messenger
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Topics |
- Animals
- Down-Regulation
- Endotoxins
(pharmacology)
- Fatty Liver
(metabolism)
- Liver
(metabolism)
- Male
- PPAR alpha
(biosynthesis, genetics)
- RNA, Messenger
(biosynthesis, genetics)
- Random Allocation
- Rats
- Rats, Wistar
- Reverse Transcriptase Polymerase Chain Reaction
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