[Cyclosporine monitoring in patients with chronic uveitis].

Abstract

BACKGROUND:

Cyclosporine (CsA) is a widely used drug in the treatment of posterior uveitis. Whereas treatment with CsA has considerably improved the visual prognosis of uveitis patients, the therapeutic benefits of CsA are partially outweighed by its adverse effects, most notably nephrotoxicity and hypertension. Recently, monitoring the CsA 2-h postdose level (C(2)) has been recommended as the most sensitive assay and predictor of clinical outcome in transplantation.

PATIENTS AND METHODS:

This prospective clinical trial included 15 patients with posterior uveitis who received oral CsA (5 mg/kg BW b.i.d.). The relationship of C(2) to C0 blood levels was analyzed and correlated with clinical safety and efficacy.

RESULTS:

A high intrapatient and interpatient variability was observed regarding the C0 values depending on several factors including comedication and intestinal resorption. C(2) values corresponded to control measurements of intraocular inflammation.

CONCLUSIONS:

C(2) monitoring offers a simple and accurate alternative for clinical monitoring of CsA. It allows the dose of CsA to be individualized effectively for each patient.

• Authors: S Schmidt, U Pleyer
• Journal: Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft (Ophthalmologe) Vol. 102 Issue 4 Pg. 349-54 (Apr 2005) ISSN: 0941-293X [Print] Germany
• Vernacular Title: Ciclosporin-Monitoring bei Patienten mit chronischer Uveitis.
• PMID: 15726383 (Publication Type: Case Reports, Clinical Trial, English Abstract, Journal Article)

Chemical References

• Immunosuppressive Agents
• Cyclosporine

Topics

• Adolescent
• Adult
• Biological Availability
• Chronic Disease
• Cyclosporine (administration & dosage, adverse effects, pharmacokinetics)
• Dose-Response Relationship, Drug
• Drug Administration Schedule
• Drug Interactions
• Drug Monitoring
• Drug Therapy, Combination
• Female
• Humans
• Immunosuppressive Agents (administration & dosage, adverse effects, pharmacokinetics)
• Male
• Metabolic Clearance Rate
• Middle Aged
• Prospective Studies
• Uveitis (blood, drug therapy)