Serotonin 2A receptor gene polymorphism and personality traits: no evidence for significant association.

Abstract

A number of studies have observed associations between the serotonin 2A (5-HT2A) receptor and mental disorders. Here, we investigated correlations between polymorphisms (-1438G/A and 102T/C) of the 5-HT2A gene and personality traits in healthy Japanese volunteers (n = 239). The personality traits were evaluated using the Revised NEO Personality Inventory (NEO PI-R). The -1438G/A and 102T/C were in complete linkage disequilibrium. There was a tendency for associations between the genotype and the scores for Agreeableness, Conscientiousness and Neuroticism of the NEO PI-R (P = 0.028, 0.039 and 0.062, respectively; analysis of variance, uncorrected for multiple testing). Subjects with the A/A of -1438G/A (or T/T of 102T/C) appeared to be lower in Neuroticism and higher in Conscientiousness than the rest of the subjects. However, the results were statistically non-significant after Bonferroni's correction for multiple testing of the five scales of the NEO PI-R. Thus, the present study provided no evidence for statistically significant associations between the 5-HT2A polymorphisms and the personality traits.

• Authors: Mamoru Tochigi, Tadashi Umekage, Chieko Kato, Tetsuya Marui, Takeshi Otowa, Hiroyuki Hibino, Toshiyuki Otani, Kazuhisa Kohda, Nobumasa Kato, Tsukasa Sasaki
• Journal: Psychiatric genetics (Psychiatr Genet) Vol. 15 Issue 1 Pg. 67-9 (Mar 2005) ISSN: 0955-8829 [Print] England
• PMID: 15722960 (Publication Type: Journal Article)

Chemical References

• Receptor, Serotonin, 5-HT2A

Topics

• Adult
• Anxiety (genetics)
• Female
• Humans
• Japan
• Linkage Disequilibrium
• Male
• Neurotic Disorders (genetics)
• Personality (genetics)
• Polymorphism, Single Nucleotide
• Receptor, Serotonin, 5-HT2A (genetics)