Abstract | BACKGROUND:
Myoepithelioma is a rare, benign tumor of the salivary gland, most commonly affecting the parotid gland. Although the cytologic features of myoepithelioma are documented in a few case reports, it has rarely been diagnosed preoperatively by fine needle aspiration (FNA) cytology. CASE: A 33-year-old man presented with a left parotid swelling 2.5 cm in diameter and of about 5 years' duration. FNA smears showed bundles of spindle-shaped cells as well as plasmacytoid and stellate cells in sheets and dissociated forms. A few cells had nuclear grooves, and occasional cells showed intranuclear cytoplasmic inclusions. In May-Grünwald-Giemsa-stained smears, most of the cells had reddish cytoplasm. Red to purple, myxoid matrix was present as a scanty fibrillar substance and as globules surrounded by tumor cells vaguely reminiscent of adenoid cystic carcinoma. A cytodiagnosis of myoepithelioma was given and corroborated by immunocytochemical staining, which revealed a positive reaction for vimentin, smooth muscle actin and S-100 protein. Epithelial membrane antigen yielded a negative reaction except for a few plasmacytoid cells with weakly positive staining. Histopathology of the resected tumor and immunohistochemical staining confirmed the cytodiagnosis of myoepithelioma. CONCLUSION: FNA cytologic features together with immunocytochemical studies on smears can offer a preoperative diagnosis of myoepithelioma.
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Authors | Dilip K Das, Bahiyah E Haji, Mahmoud S Ahmed, Mohamad N Riyad Hossain |
Journal | Acta cytologica
(Acta Cytol)
2005 Jan-Feb
Vol. 49
Issue 1
Pg. 65-70
ISSN: 0001-5547 [Print] Switzerland |
PMID | 15717758
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adult
- Biopsy, Fine-Needle
- Cytodiagnosis
- Humans
- Immunohistochemistry
- Male
- Myoepithelioma
(diagnosis, pathology)
- Parotid Neoplasms
(diagnosis, pathology)
- S100 Proteins
(chemistry)
- Staining and Labeling
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