Abstract | OBJECTIVE: METHODS: RESULTS: In immunohistochemical studies, granular PrP deposits were detected in some neurones of dorsal root ganglia and a few fibres of peripheral nerves and spinal posterior roots in one sCJD and two dCJD patients, but not in GSS102 or GSS105 patients. The atypical case of sCJD with peripheral neuropathy showed no obvious PrP deposition in the nerves. Western blotting analysis of the PNS from the dCJD patients revealed a small amount of protease K resistant PrP in the dorsal root ganglia and peripheral nerves. CONCLUSIONS: Abnormal PrP deposition occurs in the dorsal root ganglia and peripheral nerves in sCJD and dCJD. The PrP deposits in the PNS are not correlated with clinical manifestation of peripheral neuropathy in CJD.
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Authors | C Ishida, S Okino, T Kitamoto, M Yamada |
Journal | Journal of neurology, neurosurgery, and psychiatry
(J Neurol Neurosurg Psychiatry)
Vol. 76
Issue 3
Pg. 325-9
(Mar 2005)
ISSN: 0022-3050 [Print] England |
PMID | 15716520
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Autopsy
- Blotting, Western
- Creutzfeldt-Jakob Syndrome
(genetics, physiopathology)
- DNA Mutational Analysis
- Dura Mater
(transplantation)
- Female
- Ganglia, Spinal
(pathology)
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Peripheral Nervous System
(pathology)
- Peripheral Nervous System Diseases
(physiopathology)
- Prions
(analysis, genetics)
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