[Effects of intranasal cortocosteroidson on the expression of Aquaporin-5 in human nasal polyps].

Abstract

OBJECTIVE:

To observe the effects of intranasal Fluticasone propionate on the expression of Aquaporin-5 in nasal polyps and explore the role of AQP-5 in the formation of nasal polyps.

METHOD:

Twenty cases of nasal polyps were selected. Fluticasone propionate were intranasally used in 10 cases of nasal polyps for 7-10 days before operation. The others, treated with nothing, were used as control. Twenty samples nasal polyps were obtained and studied with immunochemistric technique.

RESULT:

The expression of AQP-5 positive cells in the blood vessel endothelium was statistically significantly redueced in the Fluticasone propionate-using group compared with the control group (P < 0.05). The difference of AQP-5 positive cells in mucosal epithelial and glandular epithelium was not statistically significant between the Fluticasone propionate-using group and the control group.

CONCLUSION:

(1) AQP-5 might be a vital factor for the formation edema of nasal polyps. (2) The effects of Fluticasone propionate on nasal polyps may be related to changing the expression of AQP-5 to a degree. (3) The full exploration of regulation and control of Aquaporions can contribute to evaluate the pathogenesis of nasal polyps.

• Authors: Zhihai Li, Qixue Gao, Hongtao Zhen, Yonghua Cui
• Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology (Lin Chuang Er Bi Yan Hou Ke Za Zhi) Vol. 18 Issue 11 Pg. 647-9 (Nov 2004) China
• PMID: 15715403 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)

Chemical References

• Androstadienes
• Anti-Inflammatory Agents
• Aquaporin 5
• Fluticasone

Topics

• Administration, Intranasal
• Adult
• Androstadienes (administration & dosage, therapeutic use)
• Anti-Inflammatory Agents (administration & dosage, therapeutic use)
• Aquaporin 5 (biosynthesis)
• Female
• Fluticasone
• Humans
• Male
• Middle Aged
• Nasal Polyps (drug therapy, metabolism)