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Modification of biological parameters after treatment with recombinant factor VIIa in a patient with thrombocytopathy due to storage pool disease.

Abstract
Patients with thrombocytopathy due to storage pool disease mostly suffer from mild bleeding diathesis. However surgical interventions can lead to excess bleeding. We describe how treatment with recombinant factor VIIa (Novoseven) during a surgical procedure in a boy with SPD leads to an immediate rise in PF-4, thereby activating factor Xa on the platelet surface, leading to active thrombin generation.
AuthorsL Langendonck, I M Appel
JournalPediatric blood & cancer (Pediatr Blood Cancer) Vol. 44 Issue 7 Pg. 676-8 (Jun 15 2005) ISSN: 1545-5009 [Print] United States
PMID15714444 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright 2005 Wiley-Liss, Inc.
Chemical References
  • Recombinant Proteins
  • Platelet Factor 4
  • Factor VIIa
  • Thrombin
  • Factor Xa
Topics
  • Adolescent
  • Blood Platelet Disorders (drug therapy)
  • Factor VIIa (therapeutic use)
  • Factor Xa (metabolism)
  • Humans
  • Male
  • Platelet Factor 4 (metabolism)
  • Platelet Storage Pool Deficiency (drug therapy)
  • Recombinant Proteins (therapeutic use)
  • Thrombin (metabolism)
  • Treatment Outcome

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