Blood-aqueous barrier changes after the use of prostaglandin analogues in patients with pseudophakia and aphakia: a 6-month randomized trial.

Abstract

OBJECTIVES:

To investigate the effects of prostaglandin analogues on the blood-aqueous barrier and to evaluate the occurrence of cystoid macular edema in aphakic or pseudophakic patients with glaucoma.

METHODS:

In this randomized, masked-observer, 6-month clinical trial, patients with primary open-angle, pseudophakic, or aphakic glaucoma were treated once daily with bimatoprost (n = 16), latanoprost (n = 15), or travoprost (n = 17) or twice daily with unoprostone (n = 16) or lubricant drops (control group) (n = 16). Blood-aqueous barrier status, which was assessed using a laser flare meter; intraocular pressure; the occurrence of angiographic cystoid macular edema; and conjunctival hyperemia were evaluated.

RESULTS:

Mean flare values were significantly higher in the bimatoprost, latanoprost, and travoprost groups throughout follow-up (P < .02). Four latanoprost-treated eyes, 1 bimatoprost-treated eye, and 1 travoprost-treated eye developed cystoid macular edema; all cases resolved after discontinuation of the prostaglandin analogue and treatment with topical diclofenac sodium. Mean intraocular pressure reductions after 6 months were higher for the latanoprost (26%), bimatoprost (28%), and travoprost (29%) groups than for the control (3%) and unoprostone (14%) groups (P< .05). Bimatoprost induced significantly higher hyperemia scores than latanoprost, unoprostone, and placebo (P< .01).

CONCLUSION:

Bimatoprost, latanoprost, and travoprost use may lead to disruption of the blood-aqueous barrier in patients with pseudophakia and aphakia.

• Authors: Enyr S Arcieri, Alessandro Santana, Fabiano N Rocha, Gustavo L Guapo, Vital P Costa
• Journal: Archives of ophthalmology (Chicago, Ill. : 1960) (Arch Ophthalmol) Vol. 123 Issue 2 Pg. 186-92 (Feb 2005) ISSN: 0003-9950 [Print] United States
• PMID: 15710814 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Amides
• Antihypertensive Agents
• Lipids
• Prostaglandins F, Synthetic
• Cloprostenol
• isopropyl unoprostone
• Latanoprost
• Dinoprost
• Bimatoprost
• Travoprost

Topics

• Aged
• Amides
• Antihypertensive Agents (adverse effects, therapeutic use)
• Aphakia, Postcataract (complications, drug therapy)
• Bimatoprost
• Blood-Aqueous Barrier (drug effects)
• Cloprostenol (adverse effects, analogs & derivatives, therapeutic use)
• Dinoprost (adverse effects, analogs & derivatives, therapeutic use)
• Female
• Fluorescein Angiography
• Glaucoma, Open-Angle (complications, drug therapy)
• Humans
• Intraocular Pressure (drug effects)
• Latanoprost
• Lipids (adverse effects, therapeutic use)
• Macular Edema (chemically induced, diagnosis)
• Male
• Middle Aged
• Prospective Studies
• Prostaglandins F, Synthetic (adverse effects, therapeutic use)
• Pseudophakia (complications, drug therapy)
• Safety
• Travoprost