Abstract | BACKGROUND AND OBJECTIVES: The aim of this study was to evaluate the efficacy of pegfilgrastim, in combination with salvage chemotherapy, in mobilizing CD34(+) stem cells into the peripheral blood of pretreated lymphoma patients. DESIGN AND METHODS: RESULTS: Following chemotherapy, all patients had grade 4 neutropenia that lasted a median of 1.5 days (1-3). Pegfilgrastim treatment was well tolerated and only 2/25 patients required pain-control medication. CD34+ cells were mobilized in all patients. The median (range) peak value of peripheral blood CD34+ cells after IEV chemotherapy and pegfilgrastim was 141x10(6)/L (12.8-386) and occurred almost invariably on day +14 (13-16). Twenty-three of the 25 patients underwent a single standard volume leukapheresis to collect a median of 8.7x10(6) CD34(+) cells/kg (1.78-17.3). Twenty four/25 patients (96%) reached the target cell dose of 2x10(6) CD34(+) cells/kg. High concentrations of circulating CD34+ cells (> 50x10(6)/L) were observed for several days after the achievement of the peak value. All the study patients were transplanted with their pegfilgrastim-mobilized CD34(+) cells and showed a rapid and sustained engraftment after high-dose chemotherapy. INTERPRETATION AND CONCLUSIONS:
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Authors | Alessandro Isidori, Monica Tani, Francesca Bonifazi, Pierluigi Zinzani, Antonio Curti, Maria Rosa Motta, Simonetta Rizzi, Valeria Giudice, Oriana Farese, Manuela Rovito, Lapo Alinari, Roberto Conte, Michele Baccarani, Roberto M Lemoli |
Journal | Haematologica
(Haematologica)
Vol. 90
Issue 2
Pg. 225-31
(Feb 2005)
ISSN: 1592-8721 [Electronic] Italy |
PMID | 15710576
(Publication Type: Clinical Trial, Phase II, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antigens, CD34
- Antineoplastic Agents
- Recombinant Proteins
- Granulocyte Colony-Stimulating Factor
- pegfilgrastim
- Polyethylene Glycols
- Filgrastim
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Topics |
- Adult
- Aged
- Antigens, CD34
(biosynthesis)
- Antineoplastic Agents
(therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
- Chemotherapy, Adjuvant
- Female
- Filgrastim
- Granulocyte Colony-Stimulating Factor
(administration & dosage)
- Hematopoietic Stem Cell Mobilization
(instrumentation, methods)
- Hematopoietic Stem Cells
(drug effects, metabolism)
- Humans
- Lymphoma
(therapy)
- Male
- Middle Aged
- Polyethylene Glycols
- Recombinant Proteins
- Transplantation Conditioning
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