Botulinum toxin type B: a new therapy for axillary hyperhidrosis.

Abstract

UNLABELLED:

Primary axillary hyperhidrosis is a disorder affecting mainly adolescents with significant adverse effects on quality of life. No ideal treatment exists, although recent data has demonstrated Botulinum toxin type A (Botox) as a treatment option. However, antibody formation may lead to loss of clinical benefit over time. Botulinum toxin type B (Neurobloc) has recently been introduced and may induce less immunogenic response.

OBJECTIVE:

To investigate the efficacy of Neurobloc for axillary hyperhidrosis.

METHOD:

Thirteen patients (22 axillae) were recruited to the study. The hyperhidrotic area was defined using the iodine-starch test then measured and photographed. 5000 MU of Neurobloc was administered subdermally. Patients were reviewed at 4, 8 and 12 weeks to assess outcome objectively (hyperhidrotic area measurements and photographs) and subjectively (sweat production and patient satisfaction).

RESULTS:

There was a significant reduction in hyperhidrotic area at follow-up compared to baseline. Mean percentage reduction in hyperhidrotic area was 84, 87 and 81% at 4, 8 and 12 weeks (p=0.001, paired t test). Patient satisfaction was 100% throughout. Subjective mean percentage reduction in sweat production was 98, 96 and 90 at 4, 8 and 12 weeks. Side effects were minimal.

CONCLUSION:

Neurobloc is an effective treatment for axillary hyperhidrosis.

• Authors: L Nelson, P Bachoo, J Holmes
• Journal: British journal of plastic surgery (Br J Plast Surg) Vol. 58 Issue 2 Pg. 228-32 (Mar 2005) ISSN: 0007-1226 [Print] England
• PMID: 15710119 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Neuromuscular Blocking Agents
• rimabotulinumtoxinB
• Botulinum Toxins
• Botulinum Toxins, Type A

Topics

• Adult
• Axilla
• Botulinum Toxins (therapeutic use)
• Botulinum Toxins, Type A
• Female
• Humans
• Hyperhidrosis (drug therapy)
• Male
• Neuromuscular Blocking Agents (therapeutic use)
• Pilot Projects
• Treatment Outcome