[The influence of peroxide radicals and nitric oxide on DNA synthesis in tumor cells].

The influence of peroxide radicals and nitric oxide (NO) on DNA synthesis in mouse Ehrlich's carcinoma cells was studied. Peroxyl radicals were generated from 2,2'-azo-bis(2-amidinopropane) (ABAP) and tert-buthyl hydroperoxide (t-BHP); NO was formed from sodium nitroprusside, sodium nitrite and L-arginine. The toxic effect of peroxide radicals and NO-generating compounds depended on their concentration in incubation medium. Combinations of NO donors with either ABAP or t-BHP in subtoxic concentrations did not result in marked decrease of tumor cell proliferation. The addition of non-toxic concentrations of NO generators failed or impaired the toxic effect of free radical agents. This protective action of NO may be associated with its antioxidant properties and may defend cancer cells from free-radical damage.
AuthorsI V Kondakova, G V Zagrebel'naia
JournalBiomedit︠s︡inskai︠a︡ khimii︠a︡ (Biomed Khim) Vol. 50 Issue 6 Pg. 576-81 ( 2004) ISSN: 2310-6972 [Print] Russia
Vernacular TitleVliianie kombinatsii peroksidnykh radikalov s oksidom azota na sintez DNK v opukholevykh kletkakh.
PMID15707272 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Peroxides
  • perhydroxyl radical
  • Nitric Oxide
  • DNA
  • Animals
  • Carcinoma, Ehrlich Tumor (metabolism)
  • Cell Proliferation
  • DNA (biosynthesis)
  • Mice
  • Nitric Oxide (metabolism)
  • Peroxides (metabolism)
  • Tumor Cells, Cultured

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