Alfuzosin 10 mg once daily improves sexual function in men with lower urinary tract symptoms and concomitant sexual dysfunction.

Abstract

OBJECTIVE:

To assess the effect on sexual function of alfuzosin 10 mg once daily, a uroselective alpha(1)-blocker, in men with lower urinary tract symptoms (LUTS) suggestive of bladder outlet obstruction.

PATIENTS AND METHODS:

In all, 3076 men (mean age 65.9 years) were treated for 1 year with alfuzosin 10 mg in 'real life' practice. They were asked to complete the International Prostatic Symptom Score (IPSS), its appended eighth question (bother score) and the Danish Prostatic Symptom Score questionnaire for sexual dysfunction (DAN-PSSsex). The results were analysed at the endpoint in the intent-to-treat population.

RESULTS:

At baseline, 2434 (79.1%) men were sexually active and answered correctly at least one item of the DAN-PSSsex. Sexual dysfunction was highly prevalent (reduced stiffness of erection, 65.3%; reduced volume of ejaculate, 63.2%; pain/discomfort on ejaculation, 20.2%), and was strongly related to the severity of LUTS and impairment of quality of life. At the endpoint, alfuzosin significantly improved the total IPSS (-6.1, - 32%) and bother score (-1.4, - 33.2%, both P < 0.001) over baseline. In those men with sexual dysfunction there were significant improvements in weighted scores related to reduced rigidity of erection (-0.5), reduced amount of ejaculate (-0.4) and pain/discomfort on ejaculation (-1.2, all P < 0.001) over baseline. The perceived improvements were more marked in men with severe LUTS or a severe bother score at baseline.

CONCLUSIONS:

Sexual dysfunction is highly prevalent in men with LUTS and related to the baseline IPSS and bother score. Alfuzosin 10 mg once daily for 1 year is effective in improving LUTS and quality of life, and is well tolerated. It may even improve sexual function in those men with concomitant erectile and/or ejaculatory dysfunction.

• Authors: R Jeroen A van Moorselaar, Rudolf Hartung, Mark Emberton, Niels Harving, Haim Matzkin, Mostafa Elhilali, Antonio Alcaraz, Guy Vallancien, ALF-ONE Study Group
• Journal: BJU international (BJU Int) Vol. 95 Issue 4 Pg. 603-8 (Mar 2005) ISSN: 1464-4096 [Print] England
• PMID: 15705088 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenergic alpha-Antagonists
• Quinazolines
• alfuzosin

Topics

• Adrenergic alpha-Antagonists (administration & dosage, adverse effects)
• Aged
• Ejaculation (drug effects)
• Humans
• Male
• Pain (etiology)
• Penile Erection (drug effects)
• Quality of Life
• Quinazolines (administration & dosage, adverse effects)
• Sexual Dysfunction, Physiological (drug therapy)
• Treatment Outcome
• Urinary Bladder Neck Obstruction (complications)
• Urination Disorders (etiology)