Infections in patients with Shwachman-Diamond syndrome.

Abstract

Shwachman-Diamond syndrome (OMIM 260400) is a multisystemic disorder characterized by pancreatic insufficiency, bone marrow dysfunction, skeletal abnormalities and immune dysfunction. Prompted by the case of a 13-year-old girl with Shwachman-Diamond syndrome who presented with pneumonia attributable to Pseudomonas aeruginosa, we review infectious complications of this disease. Pneumonia, recurrent otitis media and skin infections/abscesses constitute the majority of infections among these children.

• Authors: Zachary M Grinspan, Cheryl A Pikora
• Journal: The Pediatric infectious disease journal (Pediatr Infect Dis J) Vol. 24 Issue 2 Pg. 179-81 (Feb 2005) ISSN: 0891-3668 [Print] United States
• PMID: 15702050 (Publication Type: Case Reports, Journal Article, Review)

Topics

• Adolescent
• Bacterial Infections (etiology)
• Bone Marrow Diseases (complications, genetics)
• Exocrine Pancreatic Insufficiency (complications, genetics)
• Female
• Humans
• Opportunistic Infections (etiology)
• Syndrome
• Virus Diseases (etiology)