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Efficacy of paromomycin ointment in the treatment of cutaneous leishmaniasis: results of a double-blind, randomized trial in Isfahan, Iran.

Abstract
Although pentavalent antimonials are often used in the first-line treatment of cutaneous leishmaniasis (CL), they have several adverse effects. Intralesional administration of antimonials and other antileishmanial drugs can be painful. In the present, double-blind, randomized study, to determine if topical treatment with paromomycin is effective in the treatment of CL, 35 cases of CL were treated, twice daily for 30 days, with a commercial skin-care lotion containing 10% urea (the placebo) and another 30 were similarly treated with the same lotion to which paromomycin sulphate had been added (to give a concentration of 15%). Each case was assessed clinically 7, 14, 21 and 30 days after treatment began, and parasitologically 30 and 60 days after the initiation of treatment. Five (17%) and five (17%) of the cases treated with paromomycin showed complete healing, with the apparent clearance of amastigotes from their lesions, 30 and 60 days after treatment began, respectively. At the same time-points, however, the lesions on six (17%) and seven (20%) of the cases in the placebo group, respectively, also appeared to have healed completely. Ointment containing 15% paromomycin therefore appears ineffective in the treatment of CL, at least when applied twice daily for 30 days to the lesions of cases from an endemic area of Isfahan, Iran.
AuthorsF Iraji, A Sadeghinia
JournalAnnals of tropical medicine and parasitology (Ann Trop Med Parasitol) Vol. 99 Issue 1 Pg. 3-9 (Jan 2005) ISSN: 0003-4983 [Print] England
PMID15701249 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Antiprotozoal Agents
  • Ointments
  • Paromomycin
Topics
  • Administration, Topical
  • Adolescent
  • Adult
  • Antiprotozoal Agents (administration & dosage, adverse effects)
  • Child
  • Double-Blind Method
  • Female
  • Humans
  • Leishmaniasis, Cutaneous (drug therapy)
  • Male
  • Middle Aged
  • Ointments
  • Paromomycin (administration & dosage, adverse effects)
  • Treatment Outcome

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