Abstract | OBJECTIVE: To review serotonergic and dopaminergic system function in anorexia nervosa in terms of potential modulation by atypical antipsychotic medications. METHOD: A systematic review of clinical, neurobiological and functional neuroimaging findings of serotonergic and dopaminergic system activity in anorexia nervosa was conducted via MEDLINE, PsycINFO and EMBASE psychiatry databases, with a critical review of dysregulation of these systems as therapeutic targets for atypical antipsychotics, in context of evidence regarding the utility and efficacy of these medications in this syndrome. RESULTS: There is evidence of persistently altered serotonergic and dopaminergic function in anorexia nervosa independent to weight-recovery. Case reports, open-label and single-blinded studies, albeit sparse, suggest that atypical antipsychotics may be beneficial in the management of anorexia nervosa psychopathology beyond weight gain. CONCLUSIONS:
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Authors | Peter Bosanac, Trevor Norman, Graham Burrows, Peter Beumont |
Journal | The Australian and New Zealand journal of psychiatry
(Aust N Z J Psychiatry)
Vol. 39
Issue 3
Pg. 146-53
(Mar 2005)
ISSN: 0004-8674 [Print] England |
PMID | 15701063
(Publication Type: Journal Article, Review, Systematic Review)
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Chemical References |
- Antipsychotic Agents
- Serotonin
- Dopamine
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Topics |
- Anorexia Nervosa
(drug therapy, physiopathology)
- Antipsychotic Agents
(therapeutic use)
- Brain
(drug effects, physiopathology)
- Dopamine
(physiology)
- Humans
- Randomized Controlled Trials as Topic
- Serotonin
(physiology)
- Treatment Outcome
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