Abstract |
Levodopa or short-acting dopamine (DA) agonist treatment of advanced parkinsonian patients exposes striatal DA receptors to non-physiologic intermittent stimulation that contributes to the development of dyskinesias and other motor complications. To determine whether continuous dopaminergic stimulation can delay or prevent onset of motor complications, four MPTP-lesioned, levodopa-naive cynomolgus monkeys were implanted subcutaneously with apomorphine containing ethylene vinyl acetate rods. Three other MPTP-lesioned monkeys received daily injections of apomorphine. Animals receiving apomorphine rods showed improved motor function ('ON' state) within 1 day of implantation, and remained continually 'ON' for the duration of treatment (up to 6 months) without developing dyskinesias. Injected animals also showed similar improvement in motor function after each apomorphine injection. However, these primates remained 'ON' for only 90 min and within 7-10 days all developed severe dyskinesias. Implanted monkeys evidenced local irritation, which was alleviated by steroid co- therapy.
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Authors | Francesco Bibbiani, Lauren C Costantini, Raj Patel, Thomas N Chase |
Journal | Experimental neurology
(Exp Neurol)
Vol. 192
Issue 1
Pg. 73-8
(Mar 2005)
ISSN: 0014-4886 [Print] United States |
PMID | 15698620
(Publication Type: Journal Article)
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Chemical References |
- Antiparkinson Agents
- Dopamine Agonists
- Drug Implants
- Polyvinyls
- Steroids
- ethylenevinylacetate copolymer
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- Apomorphine
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Topics |
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- Animals
- Antiparkinson Agents
(administration & dosage, adverse effects)
- Apomorphine
(administration & dosage, adverse effects, blood)
- Disease Models, Animal
- Dopamine Agonists
(administration & dosage, adverse effects)
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Drug Implants
- Dyskinesias
(etiology, prevention & control)
- Inflammation
(chemically induced, drug therapy)
- Injections, Subcutaneous
- Macaca fascicularis
- Male
- Movement
(drug effects)
- Parkinsonian Disorders
(complications, drug therapy, physiopathology)
- Polyvinyls
(administration & dosage, adverse effects)
- Recovery of Function
(drug effects)
- Steroids
(therapeutic use)
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