Abstract | BACKGROUND: This study investigates a possible relationship between the effects of gamma knife (GK) on meningioma somatostatin receptors (SRs) and the high rate of early neurological improvement without tumour reduction at short-term imaging follow-up. METHODS: FINDINGS: The pre-GK SRS index was always > 1, averaging 4.44 +/- 3.20. There were no statistically significant differences between the pre-GK average values of primary (4.80 +/- 3.65) and residual (3.75 +/- 1.93) meningiomas. At the first clinical/MRI follow-up, the neurological examination had improved in 15/20 (75%) and had not changed in 5/20 patients. A corresponding slight tumour shrinkage on high-resolution MRI was documented in 3/20 cases only. The post-GK average SRS index was lower than pre-GK values both in primary (3.87 +/- 3.19) and in adjuvant (2.52 +/- 1.14) treatments, but the differences were not significant. However, the subgroup of patients with early neurological improvement showed a higher pre-GK average SRS index (5.21 +/- 3.33) and a more substantial post-GK average SRS index decrease (3.86 +/- 3.00) than the patients whose clinical condition remained stable (2.10 +/- 0.59 and 1.99 +/- 0.55, respectively). The difference between the two subgroups of patients proved to be statistically significant (P < 0.05). CONCLUSIONS: Our preliminary findings suggest a possible relationship between a decrease in the concentration of SRs on meningioma cells at short-term functional imaging follow-up after radiosurgery and early neurological improvement.
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Authors | A Nicolato, P Giorgetti, R Foroni, D Grigolato, I P Pasquin, M Zuffante, C Soda, A Tomassini, M Gerosa |
Journal | Acta neurochirurgica
(Acta Neurochir (Wien))
Vol. 147
Issue 4
Pg. 367-74; discussion 374-5
(Apr 2005)
ISSN: 0001-6268 [Print] Austria |
PMID | 15696264
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Cavernous Sinus
(diagnostic imaging, metabolism, radiation effects)
- Female
- Follow-Up Studies
- Humans
- Male
- Meningeal Neoplasms
(diagnosis, metabolism, therapy)
- Meningioma
(diagnosis, metabolism, therapy)
- Middle Aged
- Radionuclide Imaging
- Radiosurgery
- Receptors, Somatostatin
(metabolism, radiation effects)
- Recovery of Function
(radiation effects)
- Skull Base
(diagnostic imaging, metabolism, radiation effects)
- Treatment Outcome
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