Abstract | BACKGROUND: RESULTS: Phylogenetic analysis and comparison of the exon/intron organization of vertebrate (Homo, Mus, Fugu), chordate (Ciona) and invertebrate (Drosophila and Caenorhabditis) ADAMTS homologs has elucidated the evolutionary relationships of this important gene family, which comprises 19 members in humans. CONCLUSIONS: The evolutionary history of ADAMTS genes in vertebrate genomes has been marked by rampant gene duplication, including a retrotransposition that gave rise to a distinct ADAMTS subfamily (ADAMTS1, -4, -5, -8, -15) that may have distinct aggrecanase and angiogenesis functions.
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Authors | Ainsley C Nicholson, Shehre-Banoo Malik, John M Logsdon Jr, Erwin G Van Meir |
Journal | BMC evolutionary biology
(BMC Evol Biol)
Vol. 5
Pg. 11
(Feb 04 2005)
ISSN: 1471-2148 [Electronic] England |
PMID | 15693998
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- ADAM Proteins
(chemistry, metabolism)
- Amino Acid Motifs
- Animals
- Caenorhabditis elegans
- Ciona intestinalis
- Computer Simulation
- Drosophila
- Evolution, Molecular
- Expressed Sequence Tags
- Gene Duplication
- Genome
- Humans
- Introns
- Models, Genetic
- Phylogeny
- Protein Structure, Tertiary
- Software
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