HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Functional evolution of ADAMTS genes: evidence from analyses of phylogeny and gene organization.

AbstractBACKGROUND:
The ADAMTS (A Disintegrin-like and Metalloprotease with Thrombospondin motifs) proteins are a family of metalloproteases with sequence similarity to the ADAM proteases, that contain the thrombospondin type 1 sequence repeat motifs (TSRs) common to extracellular matrix proteins. ADAMTS proteins have recently gained attention with the discovery of their role in a variety of diseases, including tissue and blood disorders, cancer, osteoarthritis, Alzheimer's and the genetic syndromes Weill-Marchesani syndrome (ADAMTS10), thrombotic thrombocytopenic purpura (ADAMTS13), and Ehlers-Danlos syndrome type VIIC (ADAMTS2) in humans and belted white-spotting mutation in mice (ADAMTS20).
RESULTS:
Phylogenetic analysis and comparison of the exon/intron organization of vertebrate (Homo, Mus, Fugu), chordate (Ciona) and invertebrate (Drosophila and Caenorhabditis) ADAMTS homologs has elucidated the evolutionary relationships of this important gene family, which comprises 19 members in humans.
CONCLUSIONS:
The evolutionary history of ADAMTS genes in vertebrate genomes has been marked by rampant gene duplication, including a retrotransposition that gave rise to a distinct ADAMTS subfamily (ADAMTS1, -4, -5, -8, -15) that may have distinct aggrecanase and angiogenesis functions.
AuthorsAinsley C Nicholson, Shehre-Banoo Malik, John M Logsdon Jr, Erwin G Van Meir
JournalBMC evolutionary biology (BMC Evol Biol) Vol. 5 Pg. 11 (Feb 04 2005) ISSN: 1471-2148 [Electronic] England
PMID15693998 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • ADAM Proteins
Topics
  • ADAM Proteins (chemistry, metabolism)
  • Amino Acid Motifs
  • Animals
  • Caenorhabditis elegans
  • Ciona intestinalis
  • Computer Simulation
  • Drosophila
  • Evolution, Molecular
  • Expressed Sequence Tags
  • Gene Duplication
  • Genome
  • Humans
  • Introns
  • Models, Genetic
  • Phylogeny
  • Protein Structure, Tertiary
  • Software

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: