A randomized, double-blind study of the efficacy of fleroxacin versus trimethoprim-sulfamethoxazole in men with culture-proven chancroid.

Chancroid is linked to the spread of human immunodeficiency virus type 1 (HIV-1) in East Africa. Effective, easily administered therapy is a priority for the control of Haemophilus ducreyi. The efficacy of a single oral dose of fleroxacin, 400 mg, was compared to a 3-day oral course of trimethoprim-sulfamethoxazole (TMP-SMZ), 160/800 mg, twice daily for the treatment of chancroid in 98 HIV-1-seronegative men in Nairobi, Kenya. No differences were noted between the two groups with respect to demographic characteristics, sexual behavior, and clinical characteristics. Culture-proven failure occurred in 1 (3%) of 36 fleroxacin-treated patients and in 11 (30%) of 37 TMP-SMZ-treated patients (P = .005). Fleroxacin, as a single oral dose, is an effective treatment for culture-proven chancroid in patients who are HIV-1 seronegative. TMP-SMZ is no longer predictably effective due to the recent emergence of resistance to both sulfonamides and to trimethoprim.
AuthorsP J Plourde, L J D'Costa, E Agoki, J Ombette, J O Ndinya-Achola, L A Slaney, A R Ronald, F A Plummer
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 165 Issue 5 Pg. 949-52 (May 1992) ISSN: 0022-1899 [Print] UNITED STATES
PMID1569347 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Fleroxacin
  • Administration, Oral
  • Adult
  • Chancroid (drug therapy)
  • Double-Blind Method
  • Fleroxacin (administration & dosage, adverse effects, therapeutic use)
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Trimethoprim, Sulfamethoxazole Drug Combination (administration & dosage, adverse effects, therapeutic use)

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