HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

A randomized, double-blind study of the efficacy of fleroxacin versus trimethoprim-sulfamethoxazole in men with culture-proven chancroid.

Abstract
Chancroid is linked to the spread of human immunodeficiency virus type 1 (HIV-1) in East Africa. Effective, easily administered therapy is a priority for the control of Haemophilus ducreyi. The efficacy of a single oral dose of fleroxacin, 400 mg, was compared to a 3-day oral course of trimethoprim-sulfamethoxazole (TMP-SMZ), 160/800 mg, twice daily for the treatment of chancroid in 98 HIV-1-seronegative men in Nairobi, Kenya. No differences were noted between the two groups with respect to demographic characteristics, sexual behavior, and clinical characteristics. Culture-proven failure occurred in 1 (3%) of 36 fleroxacin-treated patients and in 11 (30%) of 37 TMP-SMZ-treated patients (P = .005). Fleroxacin, as a single oral dose, is an effective treatment for culture-proven chancroid in patients who are HIV-1 seronegative. TMP-SMZ is no longer predictably effective due to the recent emergence of resistance to both sulfonamides and to trimethoprim.
AuthorsP J Plourde, L J D'Costa, E Agoki, J Ombette, J O Ndinya-Achola, L A Slaney, A R Ronald, F A Plummer
JournalThe Journal of infectious diseases (J Infect Dis) Vol. 165 Issue 5 Pg. 949-52 (May 1992) ISSN: 0022-1899 [Print] UNITED STATES
PMID1569347 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Trimethoprim, Sulfamethoxazole Drug Combination
  • Fleroxacin
Topics
  • Administration, Oral
  • Adult
  • Chancroid (drug therapy)
  • Double-Blind Method
  • Fleroxacin (administration & dosage, adverse effects, therapeutic use)
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Trimethoprim, Sulfamethoxazole Drug Combination (administration & dosage, adverse effects, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: