[Blood plasma resistance to activated protein C as a risk factor of disseminated intravascular coagulation in acute-poisoned patients].

Abstract

The aim of this work was to assess the prevalence of the blood plasma resistance to activated protein C as a risk factor of disseminated intravascular coagulation (DIC) in acute-poisoned patients. The number of examined people was 231, including 140 acute-poisoned patients (of whom 83 showed DIC's finding) and 91 clinically healthy controls. The resistance of examined plasma to the anticoagulating properties of activated protein C was assessed by Chromogenix APC-Resistance V assay (APC-R-V). Abnormal results of APC-R-V were found to be 6-fold more frequent in acute-poisoned patients with DIC syndrome: 20 of 83 (24.1%), vs 3 of 91 (3.3%) for the control. The differences were statistically significant at p=0.0001 Mean values of coefficient R were statistically significantly lower in the acute-poisoned patients with DIC syndrome than the control, p<0.001. Genetic tests preformed in 37 patients confirmed V Leiden mutation to be present people whose R index value was below 2.0. Detection of APC-R in acute-poisoned patients could facilitate implementation of suitable preventive procedure before the DIC symptoms become manifest.

• Authors: Małgorzata Barańska, Barbara Kur, Mirosław Prazanowski, Waldemar Lutz
• Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego (Pol Merkur Lekarski) Vol. 17 Issue 100 Pg. 357-60 (Oct 2004) ISSN: 1426-9686 [Print] Poland
• Vernacular Title: Oporność osocza na aktywne białko C jako czynnik ryzyka rozsianego wykrzepiania śródnaczyniowego u chorych ostro zatrutych.
• PMID: 15690701 (Publication Type: English Abstract, Journal Article)

Chemical References

• Protein C
• Factor V

Topics

• Acute Disease
• Adult
• Case-Control Studies
• Disseminated Intravascular Coagulation (blood, etiology)
• Factor V (genetics)
• Female
• Humans
• Male
• Middle Aged
• Plasma (metabolism)
• Poisoning (blood, complications)
• Prevalence
• Protein C (metabolism)
• Risk Factors