Abstract |
A rare compound mutation involving a 36 bp deletion and 18 bp insertion within exon 5 of the dentin sialophosphoprotein (DSPP) gene has been identified in a family with dentinogenesis imperfecta type III (DGI-III). The DSPP gene encodes two major tooth matrix proteins dentin sialoprotein (DSP) and dentin phosphoprotein (DPP). DSPP mutations associated with DGI-III results in an in frame truncation of the serine aspartic acid triplet repeat found in DPP near the highly conserved carboxyl terminal region shortening the protein by six amino acids. Clinically this family presents with discolored amber opalescent teeth and severe attrition of the tooth structure. This study is the first report of a mutation within DPP associated with a genetic dentin disease. Our study indicates that DGI-III is allelic with some forms of DGI-II with and without progressive hearing loss and dentin dysplasia type II that have been shown to be caused by mutations within the DSP coding or signal peptide regions.
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Authors | Juan Dong, TingTing Gu, Leticia Jeffords, Mary MacDougall |
Journal | American journal of medical genetics. Part A
(Am J Med Genet A)
Vol. 132A
Issue 3
Pg. 305-9
(Jan 30 2005)
ISSN: 1552-4825 [Print] United States |
PMID | 15690376
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Copyright | (c) 2004 Wiley-Liss, Inc. |
Chemical References |
- Extracellular Matrix Proteins
- Phosphoproteins
- Protein Precursors
- Sialoglycoproteins
- dentin sialophosphoprotein
- DNA
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Topics |
- Amino Acid Sequence
- Base Sequence
- DNA
(chemistry, genetics)
- DNA Mutational Analysis
- Dentin
(metabolism)
- Dentinogenesis Imperfecta
(classification, genetics, pathology)
- Extracellular Matrix Proteins
- Family Health
- Female
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Pedigree
- Phosphoproteins
(genetics)
- Polymorphism, Single-Stranded Conformational
- Protein Precursors
(genetics)
- Sequence Homology, Amino Acid
- Sequence Homology, Nucleic Acid
- Sialoglycoproteins
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