[The functional status of circulating lymphoid and phagocytic cells in patients with tropical malaria, living in the endemic areas of Guinea].

Abstract

The paper presents the results of a study of immunological parameters in the indigenous adult population of an endemic area of Guinea in tropical malaria of varying severity and the time course of changes in these parameters in different phases of the disease during delagil treatment. Examination of 101 patients has established that tropical malaria in re-infected patients is not accompanied by severe immunosuppression though there is a clear tendency towards lymphocytic immunodeficiency in patients with higher parasitemia and a severe course of the disease. The greatest manifestations of immunosuppression coincide with the high oxygen metabolism of phagocytes, which confirms their important role in the pathogenesis of immune disorders and common syndrome in malaria.

• Authors: G V Bulava, B K Danilkin, N P Malinina, M Kulibali, M S Keita, V M Keita
• Journal: Meditsinskaia parazitologiia i parazitarnye bolezni (Med Parazitol (Mosk)) 2004 Oct-Dec Issue 4 Pg. 11-5 ISSN: 0025-8326 [Print] Russia (Federation)
• Vernacular Title: Funktsional'noe sostoianie tsirkuliruiushchikh limfoidnykh i fagotsitiruiushchikh kletok u bol'nykh tropicheskoĭ malarieĭ--zhiteleĭ éndemichnykh raĭonov Gvinei.
• PMID: 15689129 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antimalarials
• chloroquine diphosphate
• Chloroquine

Topics

• Adolescent
• Adult
• Antimalarials (therapeutic use)
• B-Lymphocytes (immunology)
• Blackwater Fever
• Chloroquine (analogs & derivatives, therapeutic use)
• Disease Progression
• Female
• Guinea
• Humans
• Immunologic Tests
• Lymphocyte Count
• Malaria (diagnosis, immunology)
• Male
• Middle Aged
• Parasitemia (immunology)
• Phagocytes (immunology, metabolism)
• T-Lymphocytes (immunology)