The long-term clinical results of a platelet glycoprotein IIb/IIIa receptor blocker (Abciximab: Reopro) coated stent in patients with coronary artery disease.

Abstract

BACKGROUND:

Previously, the inhibition of coronary restenosis with Abciximab (ReoPro)-coated stent in a porcine model was reported. ReoPro inhibits platelet aggregation, the proliferation of vascular smooth muscle cells and the inflammatory reaction.

METHODS:

A prospective randomized trial was performed to compare two types of stent for revascularization in the native coronary artery. The primary effective end points were major adverse coronary events (MACE): cardiac death, acute myocardial infarction, target vessel revascularization (TVR) and restenosis at the 6-month clinical and angiographic follow-ups.

RESULTS:

One hundred and fifty-five patients were enrolled between August 2001 and June 2003. The mean ages (56.0 +/- 10.0 vs. 56.9 +/- 10.8 years), baseline diameter of stenosis and minimal luminal diameter were no different between the two groups. There was one myocardial infarction and revascularization during the hospital stay in control stent group. During the clinical follow-up there were two myocardial infarctions in control group. Follow-up coronary angiograms were performed in 62.3% (48/77) and 65.4% (51/78) of the coated and control groups, respectively. The diameter of stenosis and late loss were significantly less in the ReoPro-coated stent group compared with the controls (16.4 +/- 5.8% vs. 34.3 +/- 6.1%, p = 0.009; and 0.33 +/- 0.28 mm vs. 0.88 +/- 0.41 mm; p = 0.002). The restenosis and TVR rates of the ReoPro-coated stent were relatively lower compared with the control stent [14.6% (7/48) vs. 29.4% (15/51), p = 0.062; and 9.2% (7/76) vs. 14.7% (11/75); p = 0.327].

CONCLUSION:

A ReoPro-coated stent is safe, and may be effective in the prevention of coronary restenosis.

• Authors: Weon Kim, Myung Ho Jeong, Young Joon Hong, Seng Hyun Lee, Woo Seok Park, Ju Han Kim, In Soo Kim, Myung Ja Choi, Young Keun Ahn, Jeong Gwan Cho, Jong Chun Park, Dong Lyun Cho, Hoon Kim, Jung Chaee Kang
• Journal: The Korean journal of internal medicine (Korean J Intern Med) Vol. 19 Issue 4 Pg. 220-9 (Dec 2004) ISSN: 1226-3303 [Print] Korea (South)
• PMID: 15683110 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Coated Materials, Biocompatible
• Immunoglobulin Fab Fragments
• Platelet Aggregation Inhibitors
• Platelet Glycoprotein GPIIb-IIIa Complex
• Abciximab

Topics

• Abciximab
• Antibodies, Monoclonal (pharmacokinetics, therapeutic use)
• Coated Materials, Biocompatible (pharmacokinetics, therapeutic use)
• Coronary Artery Disease (surgery)
• Coronary Restenosis (epidemiology, prevention & control)
• Female
• Humans
• Immunoglobulin Fab Fragments (therapeutic use)
• Korea (epidemiology)
• Male
• Middle Aged
• Platelet Aggregation Inhibitors (pharmacokinetics, therapeutic use)
• Platelet Glycoprotein GPIIb-IIIa Complex (antagonists & inhibitors)
• Prospective Studies
• Stents