The overall prevalence of H pylori
infection in superficial
gastritis was 28.7%, in erosive
gastritis 57.7%, in gastric erosion 63.3%, in
gastric ulcer 80.8%, in early
gastric cancer 52.4%. There was significant difference (P<0.05), except for the difference between early
gastric cancer and erosive
gastritis. H pylori
infection rate in antrum, corpus, angulus of patients with superficial
gastritis was 25.9%, 26.2%, 25.2%, respectively; in patients with erosive
gastritis 46.9%, 53.5%, 49.0%, respectively; in patients with gastric erosion 52.4%, 61.5%, 52.4%, respectively; in patients with
gastric ulcer 52.4%, 61.5%, 52.4%, respectively; in patients with early
gastric cancer 35.0%, 50.7%, 34.6%, respectively. No significant difference was found among the different site biopsies in superficial
gastritis, but in the other diseases the detected rates were higher in corpus biopsy (P<0.05). The grades of mononuclear cell infiltration and polymorphonuclear cell infiltration, in early
gastric cancer patients, were significantly higher than that in superficial
gastritis patients, lower than that in gastric erosion and
gastric ulcer patients (P<0.01); however, there was no significant difference compared with erosive
gastritis. The grades of mucosa glandular
atrophy and intestinal
metaplasia were significantly highest in early
gastric cancer, lower in
gastric ulcer, the next were erosive
gastritis, gastric erosion, the lowest in superficial
gastritis (P<0.01). Furthermore, 53.3% and 51.4% showed glandular
atrophy and intestinal
metaplasia in angular biopsy specimens, respectively; but only 40.3% and 39.9% were identified in
antral biopsy, and 14.1% and 13.6% in corpus biopsy; therefore, the angulus was more reliable for the diagnosis of glandular
atrophy and intestinal
metaplasia compared with antrum and corpus (P<0.01). The positivity rate of glandular
atrophy and intestinal
metaplasia of superficial
gastritis with H pylori-positivity was 50.7%, 34.1%; of erosive
gastritis 76.1%, 63.0%; of gastric erosion 84.8%, 87.8%; of
gastric ulcer 80.6%, 90.9%; and of early
gastric cancer 85.5%, 85.3%, respectively. The positivity rate of glandular
atrophy and intestinal
metaplasia of superficial
gastritis with H pylori-negativity was 9.9%, 6.9%; of erosive
gastritis 42.5%, 42.1%; of gastric erosion 51.1%, 61.9%; of
gastric ulcer 29.8%, 25.5%; and of early
gastric cancer 84.0%, 86.0%, respectively. The positivity rate of glandular
atrophy and intestinal
metaplasia of superficial
gastritis, erosive
gastritis, gastric erosion, and
gastric ulcer patients with H pylori positivity was significantly higher than those with H pylori negativity (P<0.01); however, there was no significant difference in patients with early
gastric cancer with or without H pylori
infection.
CONCLUSION: