HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Diet, anaerobic bacterial metabolism, and colon cancer: a review of the literature.

Abstract
Epidemiologic studies have demonstrated variations in the incidence of colon cancer between populations and socioeconomic groups. Differences in dietary habits have been implicated in the risk of developing colon cancer. Diet appears to influence our colonic microflora. Such variations may allow for future utilization of the fecal flora as markers for screening and diagnosis of colon cancer. The composition of the diet not only dictates the available substrates for the flora but also helps to establish predictable and competitive relationships between intestinal bacteria. To appreciate the significance of populations deemed high and low risk based on host flora, an understanding of several dynamic microbial relationships and metabolites produced is necessary. In this review, we explore the critical relationships between bile acid 7 alpha-dehydroxylation, sulfidogenesis, methanogenesis, and how they relate to carbohydrate and bile acid metabolism. We summarize the chemopreventative, anticarcinogenic, and detoxifying activity of probiotics and prebiotics, as well as potential mechanisms for protection against colon cancer.
AuthorsSean E McGarr, Jason M Ridlon, Phillip B Hylemon
JournalJournal of clinical gastroenterology (J Clin Gastroenterol) Vol. 39 Issue 2 Pg. 98-109 (Feb 2005) ISSN: 0192-0790 [Print] United States
PMID15681903 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
Chemical References
  • Sulfides
  • Methane
Topics
  • Bacteria, Anaerobic (isolation & purification, metabolism)
  • Colon (metabolism, microbiology)
  • Colonic Neoplasms (epidemiology, etiology, prevention & control)
  • Diet
  • Feces (chemistry, microbiology)
  • Feeding Behavior
  • Hawaii (ethnology)
  • Humans
  • Incidence
  • Intestinal Mucosa (metabolism, microbiology)
  • Japan (epidemiology)
  • Methane (metabolism)
  • Probiotics (therapeutic use)
  • Risk Factors
  • Socioeconomic Factors
  • Sulfides (metabolism)
  • United States (epidemiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: