Abstract | BACKGROUND: The aim of the study was to evaluate the efficacy and safety of transnasal butorphanol for postoperative analgesia in adult female patients undergoing lower laparoscopic surgery. METHODS: Fifty-six women undergoing lower laparoscopic surgery under general anesthesia were enrolled in the study. They were randomly divided into 2 groups (n = 28 each). Postoperatively, group 1 received transnasal butorphanol 2 mg, whereas group 2 received transnasal placebo. During a 6-h post-treatment period, we collected the following data: scores of visual analogue pain scale, demand and delivery of patient-controlled analgesia (PCA) morphine, vital signs, nausea, vomiting, and somnolence. RESULTS: Transnasal butorphanol clearly proved to have analgesic effect when compared with placebo as revealed by diminishment of visual analogue scale scores at 30 min (P = 0.043), less consumption of PCA morphine at 30-60 min (P = 0.002), and less demand of PCA morphine at 30-60 min (P = 0.001) and 60-180 min (P = 0.031). All patients displayed stable vital signs. The side effects between groups were not significantly different. CONCLUSIONS: In contrast with placebo transnasal butorphanol was effective in the treatment of postoperative pain in female patients undergoing lower laparoscopic surgery. It had minimum side effects.
|
Authors | Chin-Chen Chu, Jen-Yin Chen, Cheng-Shih Chen, Jann-Inn Tzeng, Chih-Hsin Tzeng, Pei-Shan Chiang, Jhi-Joung Wang |
Journal | Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists
(Acta Anaesthesiol Taiwan)
Vol. 42
Issue 4
Pg. 203-7
(Dec 2004)
ISSN: 1875-4597 [Print] China (Republic : 1949- ) |
PMID | 15679129
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Analgesics, Opioid
- Butorphanol
|
Topics |
- Administration, Intranasal
- Adult
- Analgesics, Opioid
(administration & dosage)
- Butorphanol
(administration & dosage, adverse effects)
- Female
- Humans
- Laparoscopy
- Middle Aged
- Pain, Postoperative
(drug therapy)
|