Abstract |
Ovarian cancer is the fifth most common cause of cancer death among women and the leading cause of gynaecological cancer death in the United States. Milk/dairy products consumption was considered to be a risk factor for ovarian cancer mainly because milk carbohydrate- lactose and galactose metabolism is toxic to oocytes. However, recent evidence does not support this hypothesis completely. We collected epidemiological studies related to the association between milk/dairy products consumption or galactose metabolism ( lactose, galactose, galactose-1-phosphate uridyltransferase, lactose/ transferase) and ovarian cancer published between January 1966 and August 2003 and found 27 items from 22 independent studies. Twenty studies were case-control studies and the other two were cohort studies. A meta-analysis method was conducted to estimate relative risk combining all relative data. In general, we did not find any association between milk/dairy products or galactose metabolism and ovarian cancer risk in this meta-analysis. The consumption of whole milk and butter, which contain relatively high amounts of fat, was positively (relative risk > 1.2), but not significantly, associated with an increased risk.
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Authors | L-Q Qin, J-Y Xu, P-Y Wang, A Hashi, K Hoshi, A Sato |
Journal | European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
(Eur J Cancer Prev)
Vol. 14
Issue 1
Pg. 13-9
(Feb 2005)
ISSN: 0959-8278 [Print] England |
PMID | 15677891
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
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Topics |
- Case-Control Studies
- Dairy Products
- Diet
- Epidemiologic Studies
- Female
- Galactose
(metabolism)
- Humans
- Ovarian Neoplasms
(epidemiology, etiology)
- Risk Factors
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