Abstract | OBJECTIVE: RESEARCH DESIGN AND METHODS: We systematically searched the medical literature (including Medline, Embase, LookSmart, and the Cochrane Library) for prospective randomized studies that used G-CSF as an adjunct to standard treatment for diabetic foot infections. Using a conventional meta-analysis, we pooled the relative risks (RRs) for outcomes of interest, including resolution of infection, wound healing, duration of antibiotic therapy, and need for various surgical interventions, using a fixed-effects model. RESULTS: Five randomized trials, with a total of 167 patients, met our inclusion criteria. The methodological quality of the studies was satisfactory. The investigators administered various G-CSF preparations parenterally for between 3 and 21 days. The meta-analysis revealed that adding G-CSF did not significantly affect the resolution of infection or the healing of the wounds but was associated with a significantly reduced likelihood of lower extremity surgical interventions (RR 0.38 [95% CI 0.20-0.69], number of patients who needed to be treated: 4.5), including amputation (0.41 [0.17-0.95], number of patients who needed to be treated: 8.6). There was no evidence of heterogeneity among the studies or of publication bias, suggesting that these conclusions are reasonably generalizable and robust. CONCLUSIONS: Adjunctive G-CSF treatment does not appear to hasten the clinical resolution of diabetic foot infection or ulceration but is associated with a reduced rate of amputation and other surgical procedures. The small number of patients who needed to be treated to gain these benefits suggests that using G-CSF should be considered, especially in patients with limb-threatening infections.
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Authors | Mario Cruciani, Benjamin A Lipsky, Carlo Mengoli, Fausto de Lalla |
Journal | Diabetes care
(Diabetes Care)
Vol. 28
Issue 2
Pg. 454-60
(Feb 2005)
ISSN: 0149-5992 [Print] United States |
PMID | 15677817
(Publication Type: Journal Article, Meta-Analysis)
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Chemical References |
- Granulocyte Colony-Stimulating Factor
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Topics |
- Amputation, Surgical
- Bacterial Infections
(drug therapy)
- Diabetic Foot
(drug therapy, microbiology, surgery)
- Granulocyte Colony-Stimulating Factor
(therapeutic use)
- Humans
- Limb Salvage
- Randomized Controlled Trials as Topic
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