Abstract | OBJECTIVE: METHODS: Fifty-seven patients with a history of unexplained abortion were enrolled as the investigation group for tests of protein C, protein S, antithrombin III (AT-III), as well as activated protein C resistance (APC-R). The control group consisted of fifty healthy women with a history of normal pregnancy and delivery. Blood samples were obtained for, measuring serum activity of protein C, protein S, AT-III, and APC-R. Patients with positive APC-R were tested for factor V ( FV) Leiden gene mutation by PCR-RFLP method. RESULTS: Of the 57 patients, 12 (21.1%), 1 (1.8%), and 5 (8.8%) cases were found with protein S, protein C, and AT-III deficiency respectively, and 13 (22.8%) cases with positive results of APC-R. Of the control group, no protein C or AT-III deficiency was ever found, whereas 2 (4.0%) volunteers were presented with protein S deficiency and 3 (6.0%) with positive results of APC-R. No FV Leiden gene mutation was identified in all the patients with positive APC-R results. Late spontaneous abortion cases had higher incidence of anticoagulation protein defect than the early cases. CONCLUSION: Anticoagulation protein defect may play a role in the pathogenesis of fetal loss, especially for those occurring in late stage of pregnancy.
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Authors | Chun-mei Bai, Shui-qing Ma, Ming-ying Gai, Lian-kai Fan, Feng-yan Ren, Guang-sheng Fan |
Journal | Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
(Chin Med Sci J)
Vol. 19
Issue 4
Pg. 290-2
(Dec 2004)
ISSN: 1001-9294 [Print] China |
PMID | 15669191
(Publication Type: Journal Article)
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Chemical References |
- Protein C
- Protein S
- factor V Leiden
- Antithrombin III
- Factor V
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Topics |
- Abortion, Habitual
(blood, etiology)
- Activated Protein C Resistance
(blood, complications, genetics)
- Adult
- Antithrombin III
(metabolism)
- Antithrombin III Deficiency
(blood, complications)
- Factor V
(genetics)
- Female
- Humans
- Point Mutation
- Protein C
(metabolism)
- Protein C Deficiency
(blood, complications)
- Protein S
(metabolism)
- Protein S Deficiency
(blood, complications)
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