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Effects of anticoagulation protein defect in maternal plasma on spontaneous abortion.

AbstractOBJECTIVE:
To investigate the mechanism of anticoagulation protein defect in the pathogenesis of unexplained recurrent miscarriage.
METHODS:
Fifty-seven patients with a history of unexplained abortion were enrolled as the investigation group for tests of protein C, protein S, antithrombin III (AT-III), as well as activated protein C resistance (APC-R). The control group consisted of fifty healthy women with a history of normal pregnancy and delivery. Blood samples were obtained for, measuring serum activity of protein C, protein S, AT-III, and APC-R. Patients with positive APC-R were tested for factor V (FV) Leiden gene mutation by PCR-RFLP method.
RESULTS:
Of the 57 patients, 12 (21.1%), 1 (1.8%), and 5 (8.8%) cases were found with protein S, protein C, and AT-III deficiency respectively, and 13 (22.8%) cases with positive results of APC-R. Of the control group, no protein C or AT-III deficiency was ever found, whereas 2 (4.0%) volunteers were presented with protein S deficiency and 3 (6.0%) with positive results of APC-R. No FV Leiden gene mutation was identified in all the patients with positive APC-R results. Late spontaneous abortion cases had higher incidence of anticoagulation protein defect than the early cases.
CONCLUSION:
Anticoagulation protein defect may play a role in the pathogenesis of fetal loss, especially for those occurring in late stage of pregnancy.
AuthorsChun-mei Bai, Shui-qing Ma, Ming-ying Gai, Lian-kai Fan, Feng-yan Ren, Guang-sheng Fan
JournalChinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih (Chin Med Sci J) Vol. 19 Issue 4 Pg. 290-2 (Dec 2004) ISSN: 1001-9294 [Print] China
PMID15669191 (Publication Type: Journal Article)
Chemical References
  • Protein C
  • Protein S
  • factor V Leiden
  • Antithrombin III
  • Factor V
Topics
  • Abortion, Habitual (blood, etiology)
  • Activated Protein C Resistance (blood, complications, genetics)
  • Adult
  • Antithrombin III (metabolism)
  • Antithrombin III Deficiency (blood, complications)
  • Factor V (genetics)
  • Female
  • Humans
  • Point Mutation
  • Protein C (metabolism)
  • Protein C Deficiency (blood, complications)
  • Protein S (metabolism)
  • Protein S Deficiency (blood, complications)

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